Dr Sascha Alles

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Assistant Professor (Tenure-track)

University of New Mexico School of Medicine

United States

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Dr. Sascha Alles is an Assistant Professor (Tenure-track) at the University of New Mexico School of Medicine, USA. His research focuses on electrophysiological properties and pain mechanisms, as demonstrated in his recent publications on human dorsal root ganglia and neuropathic pain. He employs cutting-edge techniques, including machine learning, to investigate the physiological actions of humanized anti-P2X4 scFv and its implications for chronic pain treatment.

Recent Grants

Grant: Open

A new treatment for acute pancreatitis injury and pain

Open Date: 2023-06-01

Close Date: 2028-05-01

Grant: Close

Neuroimmune mechanisms of a humanized CCK-B receptor scFv as therapy for chronic pain patients

Open Date: 2022-06-01

Close Date: 2023-08-01

Grant: Close

hiPSC-based High-Throughput Screening of Novel CCKBR scFV for Treating Acute and Chronic Pain in Female Patients

Open Date: 2021-12-01

Close Date: 2022-11-01

Grant: Close

Development of a CCKBR-targeting scFv as Therapy for Chronic Pain Patients

Open Date: 2021-10-01

Close Date: 2023-09-01

Grant: Close

Brain Penetrant scFv Antibody Block of P2X4 Receptor for the Treatment of Chronic Pain

Open Date: 2020-01-01

Close Date: 2025-01-01

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Research Assistant Professor (Joint appointment)

University of New Mexico

UNITED STATES

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Dr Sascha Alles

Research Interests

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About

Recent Grants

Articles (20)

Gabapentin’s effect on human dorsal root ganglia: Donor-specific electrophysiological and transcriptomic profiles

EXPRESS: Humanized anti-P2X4 scFv Reduces ATP-Induced P2X4 Currents and Modulates Excitability in Human DRG Neurons.

Physiological actions of a humanized P2X4 scFv on peripheral and central neurons in male mice with neuropathic pain

Visceral pain-related acute actions of cerulein on mouse and human sensory neurons

Electrophysiological Analyses of Human Dorsal Root Ganglia and Human Induced Pluripotent Stem Cell-derived Sensory Neurons From Male and Female Donors

Machine Learning Elucidates Electrophysiological Properties Predictive of Multi- and Single-Firing Human and Mouse Dorsal Root Ganglia Neurons

Machine learning elucidates electrophysiological properties predictive of multi- and single-firing human and mouse dorsal root ganglia neurons.

Rapid Generation and Molecular Docking Analysis of Single-Chain Fragment Variable (scFv) Antibody Selected by Ribosome Display Targeting Cholecystokinin B Receptor (CCK-BR) for Reduction of Chronic Neuropathic Pain

Pain-related behavioral and electrophysiological actions of dynorphin A (1-17)

Urokinase-type Plasminogen Activator-induced Mouse Back Pain Model.

Trigeminal Neuralgia as A Primary Demyelinating Disease: Potential Multimodal Evidence and Remaining Controversies.

Plant-derived natural products targeting ion channels for pain

Chronic pregabalin treatment protects against spreading depolarization and alters hippocampal synaptic characteristics in a model of familial hemiplegic migraine-type 1.

Epigenetic HDAC5 Inhibitor Reverses Craniofacial Neuropathic Pain in Mice.

Editorial: Insights in pain mechanisms 2022

Neuronal allodynic mechanisms of Slc7a5 (LAT1) in the spared nerve injury rodent model of neuropathic pain

Peroxisome proliferator-activated receptor gamma agonist ELB00824 suppresses oxaliplatin-induced pain, neuronal hypersensitivity, and spinal oxidative stress.

CCK2 receptors in chronic pain.

Single-Dose P2 X4R Single-Chain Fragment Variable Antibody Permanently Reverses Chronic Pain in Male Mice

Peripheral Voltage-Gated Cation Channels in Neuropathic Pain and Their Potential as Therapeutic Targets

Collaborators (5)

Adinarayana Kunamneni

June Bryan de la Peña

Karin Westlund High

Rajesh Khanna

Timothy Petersen

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