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Edwin Mientjes

Assistant professor

Erasmus University Medical Center

Netherlands

Research Interests

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About

Edwin Mientjes is an Assistant Professor at Erasmus University Medical Center in the Netherlands. His research focuses on Angelman syndrome, particularly the mechanisms of UBE3A and its implications in behavior and proteome restoration. Recent publications include studies on the impact of antisense oligonucleotide treatment and prenatal UBE3A expression in mouse models of Angelman syndrome.

Articles (8)

Year:

2026

Year:

2026

Year:

2026

Year:

2025

Year:

2021

Year:

2021

Year:

2020

Year:

2020

Collaborators (4)

Ype Elgersma

Full professor

Erasmus MC

NETHERLANDS

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Femke de Vrij

Associate professor

Erasmus University Rotterdam

NETHERLANDS

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Bas Lendemeijer

Assistant professor

Erasmus University Rotterdam

NETHERLANDS

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Benjamin D Philpot

Kenan Distinguished Professor

University of North Carolina

UNITED STATES

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Edwin Mientjes

Research Interests

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Articles (8)

A xenotransplantation model for reactivation of paternal UBE3A using human-specific antisense oligonucleotides

UBE3A isoform-selective and non-selective contributions to Angelman syndrome phenotypes

A robust method for primary cerebellar culture and genetic manipulation of Purkinje cells from postnatal mice

UBE3A reinstatement restores behaviorand proteome in an Angelman syndrome mouse model of imprinting defects

Antisense oligonucleotide treatment rescues UBE3A expression and multiple phenotypes of an Angelman syndrome mouse model

Secreted retrovirus-like GAG-domain-containing protein PEG10 is regulated by UBE3A and is involved in Angelman syndrome pathophysiology

Assessing the requirements of prenatal UBE3A expression for rescue of behavioral phenotypes in a mouse model for Angelman syndrome

Angelman Syndrome: From Mouse Models to Therapy

Collaborators (4)

Ype Elgersma

Femke de Vrij

Bas Lendemeijer

Benjamin D Philpot

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