Elena Lenci

Assistant Professor (RTD-A)

Università degli Studi di Napoli Federico II

Italy

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Elena Lenci is an Assistant Professor (RTD-A) at Università degli Studi di Firenze, Italy. Her research focuses on areas such as drug discovery and design, particularly in the development of peptidomimetic inhibitors and targeted therapies for glioblastoma and viral infections. Recent articles highlight her work on novel glycosylated drug conjugates, PROTACs for viral proteases, and advanced chemoinformatics methodologies.

Articles (17)

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2024

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2024

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2024

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2024

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2024

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2024

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2023

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2022

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2022

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2022

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2022

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2021

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2020

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2020

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2020

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2020

Collaborators (10)

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Antonio Rosato

Associate Professor

University of Florence

ITALY

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Vito Calderone

Associate Professor

University of Florence

ITALY

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Claudia LALLI

rennes university

FRANCE

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Francesco Saverio Di Leva

Assistant Professor

University of Naples Federico II

ITALY

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Elena Lenci

Research Interests

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Articles (17)

Development of New Peptidomimetic NADPH Oxidase Inhibitors with Antithrombotic Properties

Development of a GC-376 Based Peptidomimetic PROTAC as a Degrader of 3-Chymotrypsin-like Protease of SARS-CoV-2

Synthesis and Chemoinformatic Analysis of Fluorinated Piperidines as 3D Fragments for Fragment-Based Drug Discovery

Identification of BACE-1 inhibitors through directed C(sp3)–H activation on 5-oxo-pyrrolidine-3-carboxylic acid derivatives

A Structural Investigation of the Interaction between a GC-376-Based Peptidomimetic PROTAC and Its Precursor with the Viral Main Protease of Coxsackievirus B3

Oxime Linked Doxorubicin Glycoconjugates Improve the Specific Targeting of Glioblastoma in High-Grade Glioma Therapy

Molecular View on the <i>i</i>RGD Peptide Binding Mechanism: Implications for Integrin Activity and Selectivity Profiles

Multilayered Bioorthogonal SERS Nanoprobes Selectively Aggregating in Human Fluids: A Smart Optical Assay for β-Amyloid Peptide Quantification

Peptidomimetic Small-Molecule Inhibitors of 3CLPro Activity and Spike–ACE2 Interaction: Toward Dual-Action Molecules against Coronavirus Infections

Diversity‐Oriented Synthesis and Chemoinformatics: A Fruitful Synergy towards Better Chemical Libraries

Design and Synthesis of Novel Raman Reporters for Bioorthogonal SERS Nanoprobes Engineering

Identification of a Common Pharmacophore for Binding to MMP2 and RGD Integrin: Towards a Multitarget Approach to Inhibit Cancer Angiogenesis and Metastasis

Occurrence of Morpholine in Central Nervous System Drug Discovery

A Glucose‐Derived α‐Hydroxy Aldehyde for the Petasis Reaction: Facile Access to Polyfunctional δ‐Amino Acids

Nanostars—decorated microfluidic sensors for surface enhanced Raman scattering targeting of biomolecules

Combination of multicomponent KA2 and Pauson–Khand reactions: short synthesis of spirocyclic pyrrolocyclopentenones

Peptidomimetic toolbox for drug discovery

Collaborators (10)

Francesca Cantini

Giordano Pula

Andrea Trabocchi

Michael Assfalg

Patrick Pagano

Luciana Marinelli

Antonio Rosato

Vito Calderone

Claudia LALLI

Francesco Saverio Di Leva

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