Francesco Saverio Di Leva

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Assistant Professor

University of Naples Federico II

Italy

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About

Dr. Francesco Saverio Di Leva is an Assistant Professor at the University of Naples Federico II, Italy. His research focuses on RNA binding molecules, glioblastoma stem cells targeting, and cancer therapy innovations. Recent articles highlight his work on drug-like compounds, integrin ligands, and electrochemical devices for tumor detection, emphasizing his contribution to the field of medicinal chemistry and cancer research.

Recent Grants

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G4 in oncogene promoters as targets for anticancer drug discovery (GO-Pro)

Open Date: 2017-02-01

Close Date: 2019-01-01

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Collaborators (19)

Elena Lenci

Assistant Professor (RTD-A)

Università degli Studi di Napoli Federico II

ITALY

Francesco Saverio Di Leva

Research Interests

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About

Recent Grants

Articles (20)

Deepening bis-(thio)carbohydrazones conformational dynamics and hydrogen bond interactions in a non-protic solvent: DFT, molecular dynamics, NMR, and Raman investigations

Design, synthesis and characterization of aryl bis-guanyl hydrazones as RNA binders of C9orf72 G4C2 extended repeats

Targeting Glioblastoma Stem Cells via EphA2: Structural Insights into the RNA Aptamer A40s for Precision Therapy

Ex.50.T aptamer impairs tumor–stroma cross-talk in breast cancer by targeting gremlin-1

Switching Roles─Exploring Concentration-Dependent Agonistic versus Antagonistic Behavior of Integrin Ligands

Design, Synthesis, and Anticancer Activity of Drug-like Iron Chelators/G-Quadruplex Binders as Synergic Dual Targeting Agents

Development and Nanoparticle-Mediated Delivery of Novel MDM2/MDM4 Heterodimer Peptide Inhibitors to Enhance 5-Fluorouracil Nucleolar Stress in Colorectal Cancer Cells

Discovery of 2,3-Diaminoindole Derivatives as a Novel Class of NOD Antagonists

Paper-based electrochemical device for early detection of integrin αvβ6 expressing tumors

Pharmacological targeting of smoothened receptor cysteine-rich domain by Budesonide promotes in vitro myelination

A combined approach of structure‐based virtual screening and NMR to interrupt the PD‐1/PD‐L1 axis: Biphenyl‐benzimidazole containing compounds as novel PD‐L1 inhibitors

Exploring the 1,3-benzoxazine chemotype for cannabinoid receptor 2 as a promising anti-cancer therapeutic

Molecular View on the <i>i</i>RGD Peptide Binding Mechanism: Implications for Integrin Activity and Selectivity Profiles

Targeting the KRAS oncogene: Synthesis, physicochemical and biological evaluation of novel G-Quadruplex DNA binders.

Targeting SARS-CoV-2 Proteases and Polymerase for COVID-19 Treatment: State of the Art and Future Opportunities

Click‐Chemistry (CuAAC) Trimerization of an α v β 6 Integrin Targeting Ga‐68‐Peptide: Enhanced Contrast for in‐Vivo PET Imaging of Human Lung Adenocarcinoma Xenografts

Disulfide Bond Replacement with 1,4‐ and 1,5‐Disubstituted [1,2,3]‐Triazole on C‐X‐C Chemokine Receptor Type 4 (CXCR4) Peptide Ligands: Small Changes that Make Big Differences

Bioinformatics and Biosimulations as Toolbox for Peptides and Peptidomimetics Design: Where Are We?

GPBAR1 Activation by C6-Substituted Hyodeoxycholane Analogues Protect against Colitis

Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors

Collaborators (19)

Elena Lenci

Bruno Pagano

Cristina Sanchez

Vincenzo Abbate

Salvatore Di Maro

Valeria La Pietra

Monica Viviano

federica santoro

Andrea Trabocchi

Claudia Martini

Dominga Rogolino

Mauro Carcelli

valeria gasperi

Luciana Marinelli

Annamaria Biroccio

Claudia Finamore

Luca Pompili

Simona De Marino

stefano tomassi

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