Emyr Lloyd-Evans

PhD opportunity at Cardiff University in chemical biology , medicinal chemistry , and drug discovery , focused on developing selective chemical probes for TFEB/TFE3. The project aims to uncover the distinct roles of TFEB and TFE3 in lysosomal gene regulation and to study the consequences of inhibiting these transcription factors. The research combines biochemical and cellular assay development, high-throughput screening, computational chemistry, and structure-guided medicinal chemistry to discover and optimise novel inhibitors. This is a strong fit for students interested in transcription factors, lysosomal biology, autophagy, molecular pharmacology, and translational drug discovery. The successful candidate will work in an interdisciplinary environment spanning academic research at Cardiff University and practical drug discovery experience at the Medicines Discovery Institute (MDI), alongside a multidisciplinary team. The supervisory team includes Prof Emyr Lloyd-Evans (lead supervisor), Dr Darius McPhail, Dr Michael Paradowski, and Prof Andrew Tee (collaborator). This post is a PhD opening. No funding details, deadline, or application portal are specified in the post, so interested applicants should follow up directly with the supervisors or search Cardiff University’s doctoral opportunities for the project details.