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PhD Opportunity in Chemical Biology and Drug Discovery: TFEB/TFE3 Chemical Probes at Cardiff University Cardiff University in United Kingdom
Degree Level
PhD
Field of study
Chemistry
Funding
Available
Country
United Kingdom
University
Cardiff University
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About this position
PhD opportunity at Cardiff University in chemical biology, medicinal chemistry, and drug discovery, focused on developing selective chemical probes for TFEB/TFE3. The project aims to uncover the distinct roles of TFEB and TFE3 in lysosomal gene regulation and to study the consequences of inhibiting these transcription factors.
The research combines biochemical and cellular assay development, high-throughput screening, computational chemistry, and structure-guided medicinal chemistry to discover and optimise novel inhibitors. This is a strong fit for students interested in transcription factors, lysosomal biology, autophagy, molecular pharmacology, and translational drug discovery.
The successful candidate will work in an interdisciplinary environment spanning academic research at Cardiff University and practical drug discovery experience at the Medicines Discovery Institute (MDI), alongside a multidisciplinary team. The supervisory team includes Prof Emyr Lloyd-Evans (lead supervisor), Dr Darius McPhail, Dr Michael Paradowski, and Prof Andrew Tee (collaborator).
This post is a PhD opening. No funding details, deadline, or application portal are specified in the post, so interested applicants should follow up directly with the supervisors or search Cardiff University’s doctoral opportunities for the project details.
Funding details
Available
What's required
Motivated student interested in chemical biology, medicinal chemistry and translational drug discovery. The project involves biochemical and cellular assays, high-throughput screening, computational chemistry and structure-guided medicinal chemistry.
How to apply
No application link or formal deadline is provided in the post. Interested candidates should contact the supervisory team or monitor Cardiff University PhD openings for the advertised project.
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Review drafts and confirm requirements with the university.
Professors
Prof
United Kingdom
Research Interests
Pharmacy
Pharmaceutical Chemistry
Computational Chemistry
High-throughput Screening
Chemistry
Prof
United Kingdom
Research Interests
Cell Biology
Pharmacotherapy
Autophagy
Adipose Tissue Biology
Kinase Biology
Make your next move.
Prepare your application
Review drafts and confirm requirements with the university.