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Cardiff University

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PhD Opportunity in Chemical Biology and Drug Discovery: TFEB/TFE3 Chemical Probes at Cardiff University Cardiff University in United Kingdom

Degree Level

PhD

Field of study

Chemistry

Funding

Available

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Country

United Kingdom

University

Cardiff University

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Keywords

Chemistry
Biology
Computational Chemistry
High-throughput Screening
Autophagy
Chemical Biology
Medical Science
Pharmacy
Pharmaceutical Chemistry

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About this position

PhD opportunity at Cardiff University in chemical biology, medicinal chemistry, and drug discovery, focused on developing selective chemical probes for TFEB/TFE3. The project aims to uncover the distinct roles of TFEB and TFE3 in lysosomal gene regulation and to study the consequences of inhibiting these transcription factors.

The research combines biochemical and cellular assay development, high-throughput screening, computational chemistry, and structure-guided medicinal chemistry to discover and optimise novel inhibitors. This is a strong fit for students interested in transcription factors, lysosomal biology, autophagy, molecular pharmacology, and translational drug discovery.

The successful candidate will work in an interdisciplinary environment spanning academic research at Cardiff University and practical drug discovery experience at the Medicines Discovery Institute (MDI), alongside a multidisciplinary team. The supervisory team includes Prof Emyr Lloyd-Evans (lead supervisor), Dr Darius McPhail, Dr Michael Paradowski, and Prof Andrew Tee (collaborator).

This post is a PhD opening. No funding details, deadline, or application portal are specified in the post, so interested applicants should follow up directly with the supervisors or search Cardiff University’s doctoral opportunities for the project details.

Funding details

Available

What's required

Motivated student interested in chemical biology, medicinal chemistry and translational drug discovery. The project involves biochemical and cellular assays, high-throughput screening, computational chemistry and structure-guided medicinal chemistry.

How to apply

No application link or formal deadline is provided in the post. Interested candidates should contact the supervisory team or monitor Cardiff University PhD openings for the advertised project.

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Professors

Prof

University Name
Country flag

United Kingdom

Research Interests

Pharmacy

Pharmaceutical Chemistry

Computational Chemistry

High-throughput Screening

Chemistry

Prof

University Name
Country flag

United Kingdom

Research Interests

Cell Biology

Pharmacotherapy

Autophagy

Adipose Tissue Biology

Kinase Biology