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Eva-Maria Krämer-Albers
GermanyResearch Interests
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Articles (5)
Year:
2024
Year:
2024
The influence of a protein corona on the uptake of nanoparticles in cells has been demonstrated in various publications over the last years. Extracellular vesicles (EVs), can be seen as natural nanoparticles. However, EVs are produced under different cell culture conditions and little is known about the protein corona forming on EVs and its influence on their uptake by target cells. Here, we use a proteomic approach in order to analyze the protein composition of the EVs themselves and the protein composition of a human blood plasma protein corona around EVs. Moreover, we analyze the influence of the protein corona on EV uptake into human monocytes and compare it with the influence on the uptake of engineered liposomes. We show that the presence of a protein corona increases the uptake of EVs in human monocytes. While for liposomes this seems to be triggered by the presence of immunoglobulins in the protein corona, for EVs blocking the Fc receptors on monocytes did not show an influence of uptake. Therefore, other mechanisms of docking to the cell membrane and uptake are most like involved, demonstrating a clear difference between EVs and liposomes as technically produced nanocarriers.
Year:
2023
Year:
2023
Year:
2023
Collaborators (53)
VIKRAMSINGH GUJAR
Assistant Professor
University of Oklahoma Health Sciences Center
Estefanía Lozano-Andrés
Assistant professor
Utrecht University
Berglind Eva Benediktsdottir
Associate Professor
University of Iceland
Luke van der Koog
Scientific Staff, Other Scientific Research Staff, Onderzoeker
University of Groningen
Subhadip Ghatak
Associate Professor
University of Pittsburgh
Attila Oláh
University of Debrecen
Sabina Górska
Head of the Microbiome Immunobiology Laboratory/PhD
Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
Aija Linē
Professor
University of Latvia
Diego Kyburz
Head of Department
University Hospital Basel
Daniela Freitas
Project Leader
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
Marca Wauben
Professor Intercellular Communication
Utrecht University
Max Piffoux
Hospices Civils de Lyon
Marta Garcia-Contreras
MGH Institute of Health Professions
Sukhbir Kaur
Associate Scientist
National Institutes of Health
Jennifer Jones
Investigator; Head, Translational Nanobiology Section
National Cancer Institute
Christian Neri
INSERM
Dennis Jeppesen
Assistant Professor
Vanderbilt University School of Medicine
Vito D'Agostino
Associate Professor
University of Trento
Leandra Figueroa-Hall
Principal Investigator
Laureate Institute for Brain Research
Jerome Paggetti
Deputy Director
Luxembourg Institute of Health
Dinesh Upadhya
Associate Professor
Kasturba Medical College, Manipal
Tsuneya Ikezu
Professor
Mayo Clinic
Álvaro Compañ Bertomeu
PDI
Valencian International University
Ram Sagar
Research Associate (Faculty Member)
Johns Hopkins University School of Medicine
Igea D'Agnano
Senior scientist
Consiglio Nazionale delle Ricerche
Nilufar Ali
Assistant Research Professor
Boise State University
Júlia Costa
Principal Investigator, Group Leader
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica
Julie Constanzo
Research Scientist (CRCN INSERM)
INSERM
Dorival Mendes Rodrigues-Junior
Researcher Docent
Uppsala University
Aled Clayton
Professor of Cancer Studies
Cardiff University
Jonathan Degosserie
Co-Head of Molecular Biology
CHU UCL Namur
Eva Rohde
Head of GMP Laboratory for the Production of Human Cell Products and/or Biopharmaceuticals (e.g. extracellular vesicles, EVs)
Paracelsus Medical University
Luis Mariñas-Pardo
Head of Cell Therapies Unit
Instituto de Salud Carlos III
Jonathan Leor
Professor
Tel Aviv University
Volker Mailänder
Professor/Project Leader
University Medical Center of the Johannes Gutenberg University Mainz
Katrin Reiners
University Hospital Bonn
Stuart Hunt
Senior lecturer
University of Sheffield
Dorian Forte
Assistant Professor (junior)
University of Bologna
Catherine Martel
Full Professor
Université de Montréal
Carmen Campos-Silva
Personal Docente e Investigador
Universidad Loyola Andalucía
Tara Thompson-Felix
Assistant Professor
Yale University
Carsten Geiss
Johannes Gutenberg Universität Mainz
Maria D Mayan
Research Group Leader
Universidade de Vigo
Muhammad Nawaz
University of Salzburg
Aleksandra Inic-Kanada
Medical University of Vienna
Janne Leivo
Senior lecturer (on leave)
University of Turku
Miroslaw Kornek
Saarland University Medical Center
Sarah Glass
Research Assistant Professor
UPMC Hillman Cancer Center
Gi-Hoon Nam
Assistant Professor
Korea University
Hauke Werner
Max Planck Institute for Multidisciplinary Sciences
Anna Antoniou
Universität Wien
Liang Wu
Erasmus University Rotterdam
Celine Elie-Caille
Associate professor
FEMTO-ST Institute
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