Evelyn Rampler
Assistant Professor
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Positions (1)
Evelyn Rampler
University of Vienna
7 months ago
The University of Vienna’s Faculty of Chemistry, through the Vienna Doctoral School in Chemistry (DoSChem), is offering a fully funded PhD position in the field of Analytical Chemistry, focusing on structural mass spectrometry for plant glycolipidomics. The successful candidate will join the Rampler Lab, led by Assistant Professor Evelyn Rampler, and work at the interface of analytical chemistry, lipidomics, and plant biochemistry. The research project centers on the development and application of advanced mass spectrometry (MS)-based methodologies for the comprehensive structural elucidation of plant glycolipids, with a particular emphasis on highly glycosylated species that present significant analytical challenges. The project involves developing novel extraction and sample preparation strategies tailored to plant glycolipids, implementing advanced chromatographic separation techniques (such as RP, HILIC, and online 2D-LC), and applying state-of-the-art MS fragmentation methods including electron-activated dissociation (EAD) and multi-stage fragmentation (MSⁿ). Due to the complexity of the datasets and the limited availability of analytical standards, the project also requires multidimensional annotation strategies and computational data analysis skills (e.g., R, Python, MATLAB, or MS software). The overarching goal is to establish a global glycolipid profiling assay for different plant matrices, enabling automated, high-confidence structural elucidation. The Rampler Lab is dedicated to developing and applying high-resolution mass spectrometry and LC-MS workflows in omics research, including proteomics, metabolomics, lipidomics, and multiomics. The group is passionate about challenging molecules such as glycolipids and collaborates with national and international partners to address complex biological questions, such as plant heat resilience and climate change. The position is embedded in a vibrant, international research environment with access to high-end MS instrumentation and advanced separation technologies. The University of Vienna is committed to diversity, equity, and inclusion, and encourages applications from candidates of all backgrounds. The program language is English, and the school fosters a collaborative and open-minded atmosphere where students engage in interdisciplinary and curiosity-driven research. Eligibility: Applicants must hold a Master’s degree (or equivalent) in analytical chemistry, chemistry, or a related field. Strong interest in experimental and instrumental analytical chemistry, wet-lab experience, and motivation for hands-on method development are required. Prior experience with LC–MS is highly desirable, and programming/data analysis skills are essential. Candidates should be able to work independently and collaboratively, and possess strong English communication skills. German is appreciated but not required. Funding: The position is fully funded for 3 years (30 hours/week) with a fair and transparent salary according to the University of Vienna collective agreement. The program offers excellent training, coaching, and professional development opportunities, as well as access to public transport and a supportive work–life balance. Application: Applications must be submitted exclusively via the official DoSChem application portal. Direct email applications will not be considered. The deadline for applications is 27 March 2026, 12:00 noon. For more information about the research group, visit ramplerlab.univie.ac.at .
7 months ago
Articles (10)
Year:
2023
Background: An important goal of modern medicine is the development of products deriving from natural sources to improve environmental sustainability. In this study, humic substances (HS) and compost teas (CTs) extracted from artichoke (ART) and coffee grounds (COF) as recycled biomasses were employed on Ocimum basilicum plants to optimize the yield of specific metabolites with nutraceutical and antibacterial features by applying sustainable strategies. Methods: The molecular characteristics of compost derivates were elucidated by Nuclear Magnetic Resonance spectroscopy to investigate the structure–activity relationship between organic extracts and their bioactive potential. Additionally, combined untargeted and targeted metabolomics workflows were applied to plants treated with different concentrations of compost extracts. Results: The substances HS-ART and CT-COF improved both antioxidant activity (TEAC values between 39 and 55 μmol g−1) and the antimicrobial efficacy (MIC value between 3.7 and 1.3 μg mL−1) of basil metabolites. The metabolomic approach identified about 149 metabolites related to the applied treatments. Targeted metabolite quantification further highlighted the eliciting effect of HS-ART and CT-COF on the synthesis of aromatic amino acids and phenolic compounds for nutraceutical application. Conclusions: The combination of molecular characterization, biological assays, and an advanced metabolomic approach, provided innovative insight into the valorization of recycled biomass to increase the availability of natural compounds employed in the medical field.
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2023
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2021
Collaborators (14)
Dietmar Herndler-Brandstetter
-
Alexander Kastner
Universität Wien
Gunda Koellensperger
Professor
-
Harald Schoeny
Universität Wien
Paul Kosma
-
Benedikt Warth
Professor
Universität Wien
Petra Heffeter
Full professor
Medical University of Vienna
Walter Berger
-
Jürgen Hartler
Assistant Professor
Graz University of Technology
Felina Hildebrand
Universität Wien
Nina Troppmair
Universität Wien
Isabella Pötsch
Universität Wien
Samuel M. Meier‐Menches
-
Dominik Egger
Prof. Dr.
Leibniz University Hannover
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