Fabrizio Manetti

Professor of Medicinal Chemistry

University of Siena

Italy

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Fabrizio Manetti is a Professor of Medicinal Chemistry at the University of Siena, Italy. His research focuses on medicinal chemistry approaches in drug development, including machine learning applications for antibody-drug conjugates and novel therapeutics for diseases such as alkaptonuria. Recent publications demonstrate his interest in biocatalytic strategies, antiviral compounds against SARS-CoV-2, and the pharmacological potential of plant-derived substances.

Articles (16)

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2025

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2025

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2025

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2024

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2024

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2024

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2023

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2021

Collaborators (13)

Annalisa Santucci

University of Siena

ITALY

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Víctor López

Associate Professor

Universidad San Jorge

SPAIN

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Maria Rosalia PASCA

Professore Ordinario BIO/19

Università degli Studi di Pavia

ITALY

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Daniele Castagnolo

Professor

University College London

UNITED KINGDOM

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Giusy Tassone

University of Siena

ITALY

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Federica Pellati

University of Modena and Reggio Emilia

ITALY

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Marco Paolino

Associate Professor in Medicinal Chemistry

Università degli Studi di Siena

ITALY

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Giovanni Stelitano

University of Pavia

ITALY

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Nicoletta Galeotti

Professor

Università degli Studi di Napoli Federico II

ITALY

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Giulia Degiacomi

University of Pavia

ITALY

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Daniela Braconi

Associate Professor of Biochemistry

University of Siena

ITALY

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Laurent Roberto Chiarelli

Associate Professor

Università degli Studi di Pavia

ITALY

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Santiago Ramón-García

Universidad de Zaragoza

SPAIN

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Fabrizio Manetti

Research Interests

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Articles (16)

Machine Learning for Predicting the Drug-to-Antibody Ratio (DAR) in the Synthesis of Antibody–Drug Conjugates (ADCs)

A Comprehensive In Vitro and In Silico Approach for Targeting 4-Hydroxyphenyl Pyruvate Dioxygenase: Towards New Therapeutics for Alkaptonuria

Morita–Baylis–Hillman Adduct Chemistry as a Tool for the Design of Lysine-Targeted Covalent Ligands

Deletion of 82–85 N-Terminal Residues in SARS-CoV-2 Nsp1 Restricts Virus Replication

Consensus screening for a challenging target: the quest for P-glycoprotein inhibitors

Cooperative chemoenzymatic and biocatalytic cascades to access chiral sulfur compounds bearing C(sp3)–S stereocentres

Helichrysum stoechas (L.) Moench reduces body weight gain and modulates mood disorders via inhibition of silent information regulator 1 (SIRT1) by arzanol.

CanB, a Druggable Cellular Target in Mycobacterium tuberculosis

Cannabidiol‐rich non‐psychotropic Cannabis sativa L. oils attenuate peripheral neuropathy symptoms by regulation of CB2‐mediated microglial neuroinflammation

Zingiberene, a non-zinc-binding class I HDAC inhibitor: A novel strategy for the management of neuropathic pain

Antiviral Activity of Cannabidiolic Acid and Its Methyl Ester against SARS-CoV-2

The Veterinary Anti-Parasitic Selamectin Is a Novel Inhibitor of the Mycobacterium tuberculosis DprE1 Enzyme

Quinolines and Oxazino-quinoline Derivatives as Small Molecule GLI1 Inhibitors Identified by Virtual Screening

Survey on the Recent Advances in 4-Hydroxyphenylpyruvate Dioxygenase (HPPD) Inhibition by Diketone and Triketone Derivatives and Congeneric Compounds: Structural Analysis of HPPD/Inhibitor Complexes and Structure–Activity Relationship Considerations

Recent research results have converted gp120 binders to a therapeutic option for the treatment of HIV-1 infection. A medicinal chemistry point of view

Structural Rigidification of N-Aryl-pyrroles into Indoles Active against Intracellular and Drug-Resistant Mycobacteria

Collaborators (13)

Annalisa Santucci

Víctor López

Maria Rosalia PASCA

Daniele Castagnolo

Giusy Tassone

Federica Pellati

Marco Paolino

Giovanni Stelitano

Nicoletta Galeotti

Giulia Degiacomi

Daniela Braconi

Laurent Roberto Chiarelli

Santiago Ramón-García

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