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Filip Tadeusz Koniuszewski

Medical University of Vienna

Austria

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Research Interests

Pharmacology

80%

Biochemistry

20%

G Protein-coupled Receptor

50%

Neurochemistry

40%

Neuropharmacology

40%

Ligand Design

20%

Supramolecular Chemistry

20%

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Articles10

Navigating the complex landscape of benzodiazepine- and Z-drug diversity: insights from comprehensive FDA adverse event reporting system analysis and beyond

Article Link

Year:

2023

GABAA receptor-mediated seizure liabilities: a mixed-methods screening approach

Article Link

Year:

2023

Tricyclic antipsychotics and antidepressants can inhibit α5‐containing GABAA receptors by two distinct mechanisms

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Year:

2022

A de novo missense variant in GABRA4 alters receptor function in an epileptic and neurodevelopmental phenotype

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Year:

2022

Novel alpha6 preferring GABA-A receptor ligands based on loreclezole

Article Link

Year:

2022

IND02-05 The NeuroDeRisk toolbox: DeRisking chemical structures for neurotoxic adverse outcomes

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Year:

2022

Molecular Mingling: Multimodal Predictions of Ligand Promiscuity in Pentameric Ligand-Gated Ion Channels

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Year:

2022

A Benzodiazepine Ligand with Improved GABAA Receptor α5-Subunit Selectivity Driven by Interactions with Loop C

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Year:

2021

GABAA Receptor Ligands Often Interact with Binding Sites in the Transmembrane Domain and in the Extracellular Domain-Can the Promiscuity Code Be Cracked?

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Year:

2020

Structure-Guided Computational Methods Predict Multiple Distinct Binding Modes for Pyrazoloquinolinones in GABA<sub>A</sub> Receptors.

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Year:

2020

Collaborators8

Margot Ernst

Associate Professor

Medical University of Vienna Center for Brain Research

AUSTRIA

Florian Daniel Vogel

Universität Wien

AUSTRIA

Petra Scholze

Medical University of Vienna Center for Brain Research

AUSTRIA

Martin Krenn

Medical University of Vienna

AUSTRIA

Matias Wagner

Technical University of Munich

GERMANY

Annie Delaunois

Director, Head of Safety & Secondary Pharmacology

BELGIUM

Elisabeth Graf

Klinikum rechts der Isar der Technischen Universität München

GERMANY

Dominik S. Westphal

Technical University of Munich

GERMANY

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