Florian Ingo Schmidt

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Professor for Immunology of Infections

Rheinische Friedrich-Wilhelms-Universität Bonn

Germany

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About

Florian Ingo Schmidt is a Professor for Immunology of Infections at Rheinische Friedrich-Wilhelms-Universität Bonn, Germany. His research primarily focuses on innate immunity, inflammatory mechanisms, and viral infections, as evidenced by his recent articles on topics such as GSDMD activation, eosinophil ETosis, and the immune response to monkeypox virus. He is actively exploring therapeutic applications of nanobodies and the molecular pathways involved in antiviral defense and cell death.

Recent Grants

Grant: Close

Mechanisms and functional consequences of Y-DNA immune sensing (A01)

Open Date: 2018-01-01

Close Date:

Grant: Close

Elucidating inflammasome activation with alpaca single domain antibodies

Open Date: 2016-01-01

Close Date:

Grant: Close

Investigating inflammasome activation using camelid single-domain antibodies (VHHs)

Open Date: 2014-08-01

Close Date: 2016-07-31

Grant: Close

Investigating the molecular mechanism of inflammasome activation using custom-made camelid single-domain antibodies (VHHs)

Open Date: 2013-08-01

Close Date: 2014-07-31

Articles (19)

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2022

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2021

Collaborators (21)

Claudia Günther

University Hospital

GERMANY

Florian Ingo Schmidt

Research Interests

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About

Recent Grants

Articles (19)

IL-17A-producing NKp44(-) group 3 innate lymphoid cells accumulate in Familial Adenomatous Polyposis duodenal tissue.

Litomosoides sigmodontis microfilariae-induced eosinophil ETosis is dependent on the canonical inflammasome pathway

Multi-omics characterization of the monkeypox virus infection

Brain endothelial GSDMD activation mediates inflammatory BBB breakdown.

RNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I

NIS-Seq enables cell-type-agnostic optical perturbation screening.

Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application.

Diphtheria toxin activates ribotoxic stress and NLRP1 inflammasome-driven pyroptosis.

ASC oligomer favors caspase-1CARD domain recruitment after intracellular potassium efflux

Engineered Escherichia coli for the in situ secretion of therapeutic nanobodies in the gut.

Mitochondrial damage activates the NLRP10 inflammasome.

Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication.

Pyroptosis inhibiting nanobodies block Gasdermin D pore formation

Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection

Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever.

P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection.

Generation of an alpaca serum that induces immune-mediated crescentic glomerulonephritis in mice.

Nanobodies dismantle post-pyroptotic ASC specks and counteract inflammation in vivo.

Recessive NLRC4-Autoinflammatory Disease Reveals an Ulcerative Colitis Locus.

Collaborators (21)

Claudia Günther

Beate Mareike Kümmerer

Antonio Piras

Anne Pankow

Matthias Geyer

Fiona Moghaddas

Pablo Pelegrin

Fatima Martin-Sanchez

Ines Kaltheuner

Franklin L. Zhong

Gregor Hagelueken

Kim S. ROBINSON

Bernardo S Franklin

Thomas A. Kufer

Julia Mergner

Sandy Kroh

Veit Hornung

Sophia Davidson

Gunther Hartmann

Felix Meissner

Vigneshwaran Namasivayam

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