Pablo Pelegrin

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Spain

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Recent Grants

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Desarrollo técnico de un equipo para determinar en el punto de atención la immunosupersión de pacientes críticos con sepsis basado en la actividad del inflamasoma NLRP3

Open Date: 2022-01-01

Close Date: 2023-01-01

Grant: Close

Innovative tools to study the impact and mode of action of micro and nanoplastics on human health: towards a knowledge base for risk assessment

Open Date: 2021-04-01

Close Date: 2025-03-31

Grant: Close

Pyroptotic cell death in the crossroad of the transition from health to disease

Open Date: 2021-01-01

Close Date: 2024-01-01

Grant: Close

Proof of concept of prognostic test for critical Septic Patients based in Early Detection of NLRP3 Inflammasome impairment activation.

Open Date: 2020-10-01

Close Date: 2022-03-31

Grant: Close

Estudio clínico para valorar la reducción de la inflamación pulmonar aguda inducida por SARS-CoV-2 mediante MCC950, un inhibidor del inflamasoma NLRP3

Open Date: 2020-01-01

Close Date: 2021-01-01

Articles (16)

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Collaborators (11)

Rebecca Coll

The Queen's University Belfast

UNITED KINGDOM

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Fatima Martin-Sanchez

Assistant Professor Doctor

Universidad de Murcia

SPAIN

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Malvina Pizzuto

Université libre de Bruxelles

BELGIUM

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Kate Schroder

University of Queensland

AUSTRALIA

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Santiago Cuevas

Hospital Universitario Virgen del Rocío

SPAIN

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Sahil ADRIOUCH

Professor of Immunology and Biotherapy

Université de Rouen Faculté de Médecine et Pharmacie

FRANCE

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José Antonio Pons-Miñano

Professor of Gastroenterology and Hepatology. Chief of Hepatology. Liver Transplnt Unit.

Hospital Universitario Virgen del Rocío

SPAIN

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José Antonio García Vidal

Professor

Universidad de Murcia

SPAIN

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Florian Ingo Schmidt

Professor for Immunology of Infections

Rheinische Friedrich-Wilhelms-Universität Bonn

GERMANY

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Javier Sánchez Romero

Universidad de Murcia Facultad de Medicina

SPAIN

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Marisol Villalva

Assitant Professor

Universidad Complutense de Madrid

SPAIN

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Pablo Pelegrin

Research Interests

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Recent Grants

Articles (16)

Intrahepatic donor microbiota-based metataxonomic signature detected in organ preservation solution enables prediction of short-term liver transplant outcomes.

4-octyl itaconate reduces human NLRP3 inflammasome constitutive activation with the cryopyrin-associated periodic syndrome p.R262W, p.D305N and p.T350M variants

Gasdermin D mediates a fast transient release of ATP after NLRP3 inflammasome activation before ninjurin 1-induced lytic cell death

Multiple ASC-dependent inflammasomes drive differential pro-inflammatory cytokine production in a mouse model of tendinopathy

ASC oligomer favors caspase-1CARD domain recruitment after intracellular potassium efflux

Colostrum Features of Active and Recovered COVID-19 Patients Revealed Using Next-Generation Proteomics Technique, SWATH-MS

Polyphenols as NLRP3 inflammasome modulators in cardiometabolic diseases: a review of in vivo studies

Emerging Role of NLRP3 Inflammasome and Pyroptosis in Liver Transplantation

NLRP3 and pyroptosis blockers for treating inflammatory diseases

ASC nanobodies to counteract the consequences of inflammasome activation

Evolutionary analyses of the gasdermin family suggest conserved roles in infection response despite loss of pore-forming functionality

Effective ex vivo inhibition of cryopyrin-associated periodic syndrome (CAPS)-associated mutant NLRP3 inflammasome by MCC950/CRID3.

P2X7 receptor activation impairs antitumour activity of natural killer cells.

The future of neuroimmunology research for CNS disease therapeutics.

Lipid-protein interactions regulating the canonical and the non-canonical NLRP3 inflammasome.

Characterization of Novel Pathogenic Variants Leading to Caspase-8 Cleavage-Resistant RIPK1-Induced Autoinflammatory Syndrome.

Collaborators (11)

Rebecca Coll

Fatima Martin-Sanchez

Malvina Pizzuto

Kate Schroder

Santiago Cuevas

Sahil ADRIOUCH

José Antonio Pons-Miñano

José Antonio García Vidal

Florian Ingo Schmidt

Javier Sánchez Romero

Marisol Villalva

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