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Francis Lynn

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Associate Professor

The University of British Columbia

Canada

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About

Francis Lynn is an Associate Professor at the University of British Columbia, Canada. His research focuses on metabolic disease, insulin regulation, and stem cell biology, as evidenced by his recent articles exploring various aspects of pancreatic function and stem cell-derived therapies. Dr. Lynn’s work also delves into the interactions between different signaling pathways in islet function, contributing to advancements in the understanding of obesity and diabetes.

Recent Grants

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Function of the Mediator complex in pancreatic islet cell maturation and maintenance

Open Date: 2019-10-01

Close Date: 2024-09-30

Grant: Close

Examining the mechanistic impact of the HNF-1aG319S polymorphism on beta cell function and its contribution to early-onset type 2 diabetes

Open Date: 2018-10-01

Close Date: 2023-09-30

Grant: Close

Cell cycle regulation of human pancreatic endocrine cell development.

Open Date: 2018-04-01

Close Date: 2023-03-31

Grant: Close

A pan-transcriptional approach for maturing stem cell derived insulin producing cells

Open Date: 2017-06-01

Close Date: 2018-05-31

Grant: Close

Npas4 Regulation of Glucose Homeostasis

Open Date: 2015-07-01

Close Date: 2020-06-30

Articles (23)

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CANADA

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William Gibson

BC Children's Hospital

CANADA

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Francis Lynn

Research Interests

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About

Recent Grants

Articles (23)

NPAS4 Depletion in POMC Neurons Protects From Obesity and Alters the Feeding-regulated Transcriptome in Male Mice

Tracking Insulin- and Glucagon-Expressing Cells In Vitro and In Vivo Using a Double-Reporter Human Embryonic Stem Cell Line

CCL22-expressing Stem Cell-derived Islet Grafts Recruit Regulatory T Cells in Mice

Crosstalk between the aryl hydrocarbon receptor and hypoxia-inducible factor 1α pathways in human islet models

Novel time-resolved reporter mouse reveals spatial and transcriptional heterogeneity during alpha cell differentiation

An INSULIN and IAPP dual reporter enables tracking of functional maturation of stem cell-derived insulin producing cells

Characterizing the effects of Dechlorane Plus on β-cells: a comparative study across models and species

PDX1+ cell budding morphogenesis in a stem cell-derived islet spheroid system

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease

Single cell glucose-stimulated insulin secretion assay using nanowell-in-microwell plates

HumanIslets.com: Improving accessibility, integration, and usability of human research islet data.

Type 2 diabetes susceptibility gene GRK5 regulates physiological pancreatic β-cell proliferation via phosphorylation of HDAC5

Methylation of histone H3 lysine 4 is required for maintenance of beta cell function in adult mice

Islet amyloid polypeptide does not suppress pancreatic cancer

Human A2-CAR T Cells Reject HLA-A2<sup>+</sup>Human Islets Transplanted into Mice Without Inducing Graft-versus-host Disease

Retraction Note: Calcium-dependent transcriptional changes in human pancreatic islet cells reveal functional diversity in islet cell subtypes (Diabetologia, (2022), 65, 9, (1519-1533), 10.1007/s00125-022-05718-1)

A versatile fluorescence-quenched substrate for quantitative measurement of glucocerebrosidase activity within live cells

Human JAK1 gain of function causes dysregulated myelopoeisis and severe allergic inflammation

Spatial and transcriptional heterogeneity of pancreatic beta cell neogenesis revealed by a time-resolved reporter system

Dynamic Ins2 Gene Activity Defines β-Cell Maturity States

Recapitulating pancreatic cell–cell interactions through bioengineering approaches: the momentous role of non-epithelial cells for diabetes cell therapy

Using hiPSC-CMs to Examine Mechanisms of Catecholaminergic Polymorphic Ventricular Tachycardia

Collaborators (14)

Christopher Pin

John Priatel

Norman Rosenblum

Pan Deng

Mads Toft Søndergaard

Jessica Ewald

Jelena Kolic

James Johnson

Patrick MacDonald

Yuya Nishida

Andrew Pepper

Dan Luciani

Jennifer Bruin

William Gibson

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