Patrick MacDonald

Professor

University of Alberta

Canada

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About

Patrick MacDonald is a Professor at the University of Alberta, Canada. His research areas focus on pancreatic islet function, insulin secretion, and the molecular mechanisms underlying diabetes. Recent publications include investigations into interleukin signaling, glucagon secretion regulation, and the effects of gut microbial metabolites on pancreatic health.

Articles (19)

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2025

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2024

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2023

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2023

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2023

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2022

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2021

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2020

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2020

Collaborators (18)

Michala Prause

Københavns Universitet

DENMARK

Patrick MacDonald

Research Interests

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About

Articles (19)

The Gut Microbial Metabolite Butyrate Alleviates IL-1β-Induced Mitochondrial Dysfunction and Oxidative Stress in Pancreatic Islets

TMEM55A-mediated PI5P signalling regulates alpha cell actin depolymerisation and glucagon secretion

Peptidylglycine alpha-amidating monooxygenase is important in mice for beta-cell cilia formation and insulin secretion but promotes diabetes risk through beta-cell independent mechanisms

Heparan sulfate fine-tuned interleukin (IL)-1 signaling inhibits insulin secretion of grafted pancreatic islets

Molecular correlates of glycine receptor activity in human β cells

Cisplatin exposure dysregulates insulin secretion in male and female mice.

Lessons from a model: early glucagon dysfunction in type 2 diabetes.

An INSULIN and IAPP dual reporter enables tracking of functional maturation of stem cell-derived insulin producing cells

Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice

HumanIslets.com: Improving accessibility, integration, and usability of human research islet data.

Dynamic Glucose-Stimulated Insulin Secretion using Biorep Perifusion Machine (ver peri4.2) - Human or Mouse Islets

Human Islet Isolation Media Preparation

FK506-Binding Protein 2 Participates in Proinsulin Folding

CODEX ® Multiplexed Imaging – tissue staining in TMA and whole tissue FFPE sections

HNF1α maintains pancreatic α and β cell functions in primary human islets.

Ca2+ Oscillations, Waves, and Networks in Islets From Human Donors With and Without Type 2 Diabetes

Novel mouse model expands potential human α-cell research

Molecular and functional profiling of human islets: from heterogeneity to human phenotypes

Improved glucose tolerance with DPPIV inhibition requires β‐cell SENP1 amplification of glucose‐stimulated insulin secretion

Collaborators (18)

Michala Prause

Tenna Holgersen Bryde

Leticia Prates Roma

Justyna Klusek

Aliya F Spigelman

Kamil Gotfryd

Per Hägglund

Yi-Chun Chen

Andrew Pepper

Rafael Arrojo e Drigo

Charles Chang

Francis Lynn

Anna Gloyn

Julia Durzyńska

Celina Pihl

Pontus Gourdon

Anna Martinez Casals

Michal Marzec

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