Francisco Olmo Arévalo

Assistant Professor

London School of Hygiene & Tropical Medicine

United Kingdom

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Research Interests

Pharmacology

80%

Pharmaceutical Chemistry

60%

Heterocyclic Chemistry

30%

Parasitology

30%

Biostimulant

30%

Adverse Drug Reaction

30%

Insecticide Toxicology

30%

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Articles17

Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose

Year:

2023

Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice

Year:

2023

Preclinical data do not support the use of amiodarone or dronedarone as antiparasitic drugs for Chagas disease at the approved human dosing regimen

Year:

2023

Dissecting the interstrand crosslink DNA repair system of Trypanosoma cruzi.

Year:

2023

Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose

Year:

2023

Dissecting the interstrand crosslink DNA repair system of Trypanosoma cruzi

Year:

2023

Preclinical data do not support the use of amiodarone or dronedarone as antiparasitic drugs for Chagas disease at the approved human dosing regimen

Year:

2023

Image-Based In Vitro Screening Reveals the Trypanostatic Activity of Hydroxymethylnitrofurazone against Trypanosoma cruzi

Year:

2021

Bioluminescent:Fluorescent Trypanosoma cruzi Reporter Strains as Tools for Exploring Chagas Disease Pathogenesis and Drug Activity

Year:

2021

Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale.

Year:

2021

Design and synthesis of Mannich base-type derivatives containing imidazole and benzimidazole as lead compounds for drug discovery in Chagas Disease

Year:

2021

Design and synthesis of Mannich base-type derivatives containing imidazole and benzimidazole as lead compounds for drug discovery in Chagas Disease

Year:

2021

Challenges in Chagas Disease Drug Development

Year:

2020

Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection

Year:

2020

Drug-cured experimental Trypanosoma cruzi infections confer long-lasting and cross-strain protection

Year:

2020

Trypanosoma cruzi amastigotes that persist in the colon during chronic stage murine infections have a reduced replication rate

Year:

2020

Non-invasive monitoring of drug action: A new live in vitro assay design for Chagas’ disease drug discovery

Year:

2020

Collaborators5

Martin Taylor

Associate Professor of Molecular Biology

London School of Hygiene & Tropical Medicine

UNITED KINGDOM

Amanda Fortes Francisco

Assistant Professor

London School of Hygiene & Tropical Medicine

UNITED KINGDOM

Michael Lewis

Associate Professor

University of Warwick

UNITED KINGDOM

Veronica Alcolea

University of Oxford

UNITED KINGDOM

Susan Charman

MONASH UNIVERSITY

AUSTRALIA

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