Francisco Olmo Arévalo

Assistant Professor

London School of Hygiene & Tropical Medicine

United Kingdom

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Articles (17)

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2023

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2023

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2023

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2023

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2021

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2021

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2020

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2020

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2020

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2020

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2020

Collaborators (7)

Martin Taylor

Associate Professor of Molecular Biology

London School of Hygiene & Tropical Medicine

UNITED KINGDOM

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Amanda Fortes Francisco

Assistant Professor

London School of Hygiene & Tropical Medicine

UNITED KINGDOM

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Sam Alsford

Associate Professor

London School of Hygiene & Tropical Medicine

UNITED KINGDOM

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Michael Lewis

Associate Professor

University of Warwick

UNITED KINGDOM

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Veronica Alcolea

University of Oxford

UNITED KINGDOM

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Susan Charman

MONASH UNIVERSITY

AUSTRALIA

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Conor McCann

Lecturer (Regenerative Medicine)

UCL

UNITED KINGDOM

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Francisco Olmo Arévalo

Research Interests

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Articles (17)

Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose

Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice

Preclinical data do not support the use of amiodarone or dronedarone as antiparasitic drugs for Chagas disease at the approved human dosing regimen

Dissecting the interstrand crosslink DNA repair system of Trypanosoma cruzi.

Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose

Dissecting the interstrand crosslink DNA repair system of Trypanosoma cruzi

Preclinical data do not support the use of amiodarone or dronedarone as antiparasitic drugs for Chagas disease at the approved human dosing regimen

Image-Based In Vitro Screening Reveals the Trypanostatic Activity of Hydroxymethylnitrofurazone against Trypanosoma cruzi

Bioluminescent:Fluorescent Trypanosoma cruzi Reporter Strains as Tools for Exploring Chagas Disease Pathogenesis and Drug Activity

Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale.

Design and synthesis of Mannich base-type derivatives containing imidazole and benzimidazole as lead compounds for drug discovery in Chagas Disease

Design and synthesis of Mannich base-type derivatives containing imidazole and benzimidazole as lead compounds for drug discovery in Chagas Disease

Challenges in Chagas Disease Drug Development

Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection

Drug-cured experimental Trypanosoma cruzi infections confer long-lasting and cross-strain protection

Trypanosoma cruzi amastigotes that persist in the colon during chronic stage murine infections have a reduced replication rate

Non-invasive monitoring of drug action: A new live in vitro assay design for Chagas’ disease drug discovery

Collaborators (7)

Martin Taylor

Amanda Fortes Francisco

Sam Alsford

Michael Lewis

Veronica Alcolea

Susan Charman

Conor McCann

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