Amanda Fortes Francisco

Assistant Professor

London School of Hygiene & Tropical Medicine

United Kingdom

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Amanda Fortes Francisco is an Assistant Professor at the London School of Hygiene and Tropical Medicine in the UK. Her research focuses on Chagas disease, with recent publications exploring anti-trypanosomal therapies, the pathogenesis of Trypanosoma cruzi infection, and the use of animal models in drug discovery. Her contributions also include studies on the efficacy of treatments and the impacts of Chagas disease on cardiac and digestive health.

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2020

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2020

Collaborators (16)

Martin Taylor

Associate Professor of Molecular Biology

London School of Hygiene & Tropical Medicine

UNITED KINGDOM

Amanda Fortes Francisco

Research Interests

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Articles (22)

Anti-trypanosomal quinazolines targeting lysyl-tRNA-synthetase show partial efficacy in a mouse model of acute Chagas disease

Intermittent suppressive posaconazole therapy is ineffective at mitigating cardiac and digestive tract pathologies in an experimental model of chronic Chagas disease

Statins do not reduce the parasite burden during experimental Trypanosoma cruzi infection

Dynamics of Trypanosoma cruzi infection in hamsters and novel association with progressive motor dysfunction

A panel of phenotypically and genotypically diverse bioluminescent:fluorescent Trypanosoma cruzi strains as a resource for Chagas disease research

Enteric nervous system regeneration and functional cure of experimental digestive Chagas disease with trypanocidal chemotherapy

Synthesis and Anti-Chagas Activity Profile of a Redox-Active Lead 3-Benzylmenadione Revealed by High-Content Imaging

Animal models for exploring Chagas disease pathogenesis and supporting drug discovery

Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose

Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections

Collaborative Virtual Screening Identifies a 2-Aryl-4-aminoquinazoline Series with Efficacy in an <i>In Vivo</i> Model of <i>Trypanosoma cruzi</i> Infection

Short-course combination treatment for experimental chronic Chagas disease

Cardiac Abnormalities in a Predictive Mouse Model of Chagas Disease

Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice

Preclinical data do not support the use of amiodarone or dronedarone as antiparasitic drugs for Chagas disease at the approved human dosing regimen

Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection

Comparing in vivo bioluminescence imaging and the Multi-Cruzi immunoassay platform to develop improved Chagas disease diagnostic procedures and biomarkers for monitoring parasitological cure

Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor

Image-Based In Vitro Screening Reveals the Trypanostatic Activity of Hydroxymethylnitrofurazone against Trypanosoma cruzi

Bioluminescent:Fluorescent Trypanosoma cruzi Reporter Strains as Tools for Exploring Chagas Disease Pathogenesis and Drug Activity

Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy

Challenges in Chagas Disease Drug Development

Collaborators (16)

Martin Taylor

Andrew Marshall

Avninder Bhambra

Nicholas P. West

Richard J. Wall

Sam Alsford

John Kelly

Michael Lewis

George Weaver

Pascal Mäser

Scott Franzblau

Colin Jackson

Francisco Olmo Arévalo

Susan Charman

Conor McCann

Manu De Rycker

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