Frank Klont

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Assistant Professor in Personalized Pharmacotherapy

University Medical Center Groningen

Netherlands

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About

Frank Klont is an Assistant Professor in Personalized Pharmacotherapy at the University Medical Center Groningen. He is engaged in research areas including pharmacometabolomics, drug metabolism in kidney transplant recipients, and biomarkers in chronic obstructive pulmonary disease. His recent articles explore the interactions and effects of various pharmaceuticals in clinical settings.

Recent Grants

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Exposure Analytics: molecular evidence of daily-life chemical exposures

Open Date: 2022-08-01

Close Date:

Grant: Close

Molecular evidence for lifestyle habits

Open Date: 2020-05-01

Close Date: 2022-04-30

Articles (17)

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2025

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2021

Collaborators (4)

Gérard Hopfgartner

Professor

University of Geneva

SWITZERLAND

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Marcel Kwiatkowski

Assistent Professor

University of Innsbruck

AUSTRIA

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Hans Blokzijl

University Medical Center Groningen

NETHERLANDS

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Arjan Diepstra

University Medical Center Groningen

NETHERLANDS

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Frank Klont

Research Interests

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About

Recent Grants

Articles (17)

The Calprotectin Fragment, CPa9-HNE, Is a Plasma Biomarker of Mild Chronic Obstructive Pulmonary Disease

Pharmacometabolomics Study of Sulfamethoxazole and Trimethoprim in Kidney Transplant Recipients: Real-World Metabolism and Urinary Excretion

Dose, Kidney Function, and a Drug–Excipient Interaction Impair Mycophenolate Mofetil Prodrug Activation in Kidney Transplant Recipients

Pharmacometabolomics Detects Various Unreported Metoprolol Metabolites in Urine of (Potential) Living Kidney Donors and Kidney Transplant Recipients

A pharmacological view on accounting for pharmacokinetic factors in the estimation of pharmaceutical emissions based on drug usage data

Pharmacometabolomics Enables Real-World Drug Metabolism Sciences

High-abundance peaks and peak clusters associate with pharmaceutical polymers and excipients in urinary untargeted clinical metabolomics data: exploration of their origin and possible impact on label-free quantification

Proton Pump Inhibitor Use, Fatigue, and Health-Related Quality of Life in Kidney Transplant Recipients

Plasma sRAGE levels strongly associate with centrilobular emphysema assessed by HRCT scans.

Assessing the Potential of Untargeted SWATH Mass Spectrometry-Based Metabolomics to Differentiate Closely Related Exposures in Observational Studies

Untargeted ‘SWATH’ mass spectrometry-based metabolomics for studying chronic and intermittent exposure to xenobiotics in cohort studies

Association of diuretic use with increased risk for long-term post-transplantation diabetes mellitus in kidney transplant recipients

Adsorptive Microtiter Plates As Solid Supports in Affinity Purification Workflows.

Mass spectrometry based approaches and strategies in bioanalysis for qualitative and quantitative analysis of pharmaceutically relevant molecules

Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD

Metabolomics data complemented drug use information in epidemiological databases: pilot study of potential kidney donors

Clustering and Nonclustering Modifier Mixtures in Differential Mobility Spectrometry for Multidimensional Liquid Chromatography Ion Mobility–Mass Spectrometry Analysis

Collaborators (4)

Gérard Hopfgartner

Marcel Kwiatkowski

Hans Blokzijl

Arjan Diepstra

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