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Frank W. Sellke

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Chief of Cardiothoracic Surgery

Rhode Island Hospital

United States

Research Interests

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Professors in United States Professors in Cell Biology Cell Biology professors in United States

About

Frank W. Sellke is an Associate Professor at the Alpert Medical School of Brown University, USA. His research interests focus on cardiac function, ischemia, and therapeutic strategies for cardiovascular diseases, as evidenced by his recent publications on mitochondrial reactive oxygen species, sex-specific myocardial function improvements, and the role of various inhibitors in cardiac health. His work aims to enhance understanding and treatment options for conditions like chronic myocardial ischemia and metabolic syndrome.

Recent Grants

Grant: Close

Vascular Dysfunction in Myocardial Ischemia and metabolic Syndrome

Open Date: 2016-04-01

Close Date: 2020-06-30

Grant: Close

Angiogenesis in a model of diabetes and endothelial dysfunction

Open Date: 2008-08-01

Close Date: 2010-05-31

Grant: Close

Microarray gene expression profiles after cardiac surgery and their correlation to neurocognitive decline and other clinical outcomes

Open Date: 2005-10-01

Close Date: 2006-09-30

Grant: Close

Cardiovascular Surgery Research Training Grant

Open Date: 2004-04-01

Close Date: 2009-03-31

Grant: Close

Surgical Intramyocardial Angiogenesis in a Model of Endothelial Dysfunction

Open Date: 2001-12-01

Close Date: 2012-07-31

Articles (28)

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UNITED STATES

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Meghamsh Kanuparthy

Brown University

UNITED STATES

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Frank W. Sellke

Research Interests

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About

Recent Grants

Articles (28)

Commentary: Why do we still not know what causes vasoplegia?

Prediction of Cyanotic Congenital Heart Disease Risk in U.S. Births

Reply: Metformin and other drugs used to treat diabetes: Should their use be expanded to patients without diabetes and after cardiac surgery?

Semaglutide augments vascular proliferation and cardiac performance in a large animal model of ischemic cardiomyopathy

Sotagliflozin Enhances Left Ventricular Function and Myocardial Perfusion in Chronic Myocardial Ischemia Through Metabolic and Redox Remodeling

Bioengineered Cellular and Acellular Therapies for Ischemic Heart Disease in Clinically Relevant Models

Targeting Mitochondrial Reactive Oxygen Species: JP4-039’s Potential as a Cardiovascular Therapeutic

Sex-Specific Improvements in Myocardial Function and Angiogenesis with SGLT-2 Inhibitor Canagliflozin in a Swine Model of Metabolic Syndrome

Lab-grown, 3D extracellular matrix particles improve cardiac function and morphology in myocardial ischemia

Dipeptidyl peptidase-4 inhibitor linagliptin improves fibrosis, apoptosis, and cardiac function in a large animal model of chronic myocardial ischemia

Semaglutide Improves Myocardial Perfusion and Performance in a Large Animal Model of Coronary Artery Disease

Beyond Glycemic Control: Vascular Biologic Effects of Antidiabetic Drugs and Their Cardiovascular Promise

Intramyocardial Injection of Hypoxia-Conditioned Extracellular Vesicles Modulates Response to Oxidative Stress in the Chronically Ischemic Myocardium

Sodium-Glucose Cotransporter-2 Inhibition Normalizes Metabolic Derangements in the Ischemic Myocardium

Bleeding After Cardiovascular Surgery: A Continuing Problem

Patients with uncontrolled hypertension subjected to cardiopulmonary bypass have altered coronary vasomotor responses to serotonin

Cardioprotection in cardiovascular surgery

Proteomic Profiling of SGLT-2 Inhibitor Canagliflozin in a Swine Model of Chronic Myocardial Ischemia

Sitagliptin therapy improves myocardial perfusion and arteriolar collateralization in chronically ischemic myocardium: A pilot study

Reduction in mitochondrial ROS improves oxidative phosphorylation and provides resilience to coronary endothelium in non-reperfused myocardial infarction

Canagliflozin Improves Myocardial Perfusion, Fibrosis, and Function in a Swine Model of Chronic Myocardial Ischemia

Impaired cardiac glycolysis and glycogen depletion are linked to poor myocardial outcomes in juvenile male swine with metabolic syndrome and ischemia

Invited commentary on Kowalewski M, Pasierski M, Makhoul M, et al. Topical vancomycin for sternal wound infection prophylaxis. A systematic review and updated meta-analysis of over 40,000 cardiac surgery patients

Clinical uses of epigenetics in cardiology and cardiothoracic surgery: an update

Comparative Analysis of Normoxia- and Hypoxia-Modified Extracellular Vesicle Therapy in Function, Perfusion, and Collateralization in Chronically Ischemic Myocardium

Proteomic Assessment of Hypoxia-Pre-Conditioned Human Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles Demonstrates Promise in the Treatment of Cardiovascular Disease

Assessments of microvascular function in organ systems

Preoperative fibrinogen before the repair of type A aortic dissection: Are the results too good to be true?

Collaborators (8)

Jun Feng

Marwan Saad

Boian Alexandrov

Peter Wipf

Ruhul Abid

Peng Zhang

Anny Usheva

Meghamsh Kanuparthy

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