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Gary Richard Mirams

Professor of Mathematical Physiology / Wellcome Trust Senior Research Fellow

University of Nottingham

United Kingdom

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Research Interests

Cardiology

70%

Pharmacology

30%

Electrophysiology

40%

Cardiovascular Biology

30%

Ischemic Physiology

30%

Pharmacometrics

30%

Cardiovascular Risk

30%

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Recent Grants

Grant: Close

Developing cardiac electrophysiology models for drug safety studies

Open Date: 2019-02-01

Close Date: 2024-02-01

Grant: Close

Sinusoidal voltage protocols for characterisation of ion channel kinetics

Open Date: 2019-01-01

Close Date: 2021-12-31

Grant: Close

Reproducible development of mathematical models of cardiac electrophysiology

Open Date: 2017-05-01

Close Date: 2020-04-30

Grant: Close

Improving assessment of drug-induced cardiac risk with mathematical electrophysiology models.

Open Date: 2014-02-01

Close Date: 2019-01-31

Grant: Close

Prediction of human cardiotoxic QT prolongation using in-vitro multiple ion channel data and mathematical models of cardiac myocytes

Open Date: 2013-02-14

Close Date: 2014-04-12

Articles20

Neural network emulation of the human ventricular cardiomyocyte action potential for more efficient computations in pharmacological studies

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Year:

2024

Optimal experimental designs for characterising ion channel gating by filling the phase-voltage space of model dynamics

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Year:

2024

A range of voltage-clamp protocol designs for rapid capture of hERG kinetics

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Year:

2024

Ten simple rules for training scientists to make better software

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Year:

2024

An experimental investigation of rundown of the L-type calcium current

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Year:

2024

The impact of uncertainty in hERG binding mechanism on in silico predictions of drug‐induced proarrhythmic risk

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Year:

2024

Understanding the impact of numerical solvers on inference for differential equation models

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Year:

2024

Empirical Quantification of Predictive Uncertainty Due to Model Discrepancy by Training with an Ensemble of Experimental Designs: An Application to Ion Channel Kinetics

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2024

Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings

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Year:

2023

Model-driven optimal experimental design for calibrating cardiac electrophysiology models

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Year:

2023

chaste codegen: automatic CellML to C++ code generation with fixes for singularities and automatically generated Jacobians

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Year:

2021

Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243

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Year:

2021

Cardiac TdP risk stratification modelling of anti-infective compounds including chloroquine and hydroxychloroquine

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Year:

2021

Considering discrepancy when calibrating a mechanistic electrophysiology model

Article Link

Year:

2020

Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments

Article Link

Year:

2020

Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk

Article Link

Year:

2020

A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer

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Year:

2020

Calibration of ionic and cellular cardiac electrophysiology models

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Year:

2020

The fickle heart: uncertainty quantification in cardiac and cardiovascular modelling and simulation

Article Link

Year:

2020

A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm

Article Link

Year:

2020

Collaborators16

Neil Herring

University of Oxford

UNITED KINGDOM

Glen F. Tibbits

CANADA

Teun de Boer

Associate Professor

University Medical Center Groningen

NETHERLANDS

Gundolf Haase

Univ.-Prof.

Graz University of Technology

AUSTRIA

david gavaghan

University of Oxford

UNITED KINGDOM

Richard Wilkinson

Professor of Statistics

University of Nottingham

UNITED KINGDOM

Michael Clerx

UNITED KINGDOM

Maurice Hendrix

TNO

NETHERLANDS

Wendy Wu

Senior Pharmacokineticist / Principal Investigator / Lab Head

US Food and Drug Administration

UNITED STATES

Jonathan Cooper

University College London

UNITED KINGDOM

Rebecca-Ann Burton

University of Oxford

UNITED KINGDOM

Kit Gallagher

University of Oxford

UNITED KINGDOM

David J. Christini

SUNY Downstate Health Sciences University

UNITED STATES

Chris D. Cantwell

Imperial College London

UNITED KINGDOM

Marina Riabiz

King's College London

UNITED KINGDOM

Yasser Aboelkassem

Assistant Professor

University of Michigan - Flint

UNITED STATES

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