Genta Kakiyama

Associate Professor

University of Virginia School of Medicine

United States

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Dr. Genta Kakiyama is an Associate Professor at Virginia Commonwealth University School of Medicine in the United States. His research primarily focuses on liver diseases, including nonalcoholic fatty liver disease and its metabolic implications, with particular emphasis on the roles of various molecular pathways and metabolites. Recent publications highlight his work on topics such as ER stress response in hepatocytes, bile acid profiles in pediatric patients, and the impact of diet on liver health.

Articles (14)

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2025

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2021

Collaborators (5)

Saori Oguri

Oita University Hospital

JAPAN

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Jia Wen

Duke University

UNITED STATES

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Hisamitsu Hayashi

Associate Professor

University of Tokyo

JAPAN

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Rebecca Martin

Assistant Professor

Virginia Commonwealth University

UNITED STATES

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Mitsuyoshi Suzuki

JAPAN

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Genta Kakiyama

Research Interests

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Articles (14)

StarD5 Plays a Critical Role in the Hepatocyte ER Stress Survival Response

Liver specific transgenic expression of CYP7B1 attenuates early western diet-induced MASLD progression

Fecal fatty acid-linked bile acid profiles in pediatric patients with ulcerative colitis

StarD5 levels of expression correlate with onset and progression of steatosis and liver fibrosis

StarD5 modulates B cell cholesterol synthesis and IgG1 plasma cell differentiation

Mitochondrial Cholesterol Metabolites in a Bile Acid Synthetic Pathway Drive Nonalcoholic Fatty Liver Disease: A Revised “Two-Hit” Hypothesis

Dried blood spot-based newborn screening for bile acid synthesis disorders, Zellweger spectrum disorder, and Niemann-Pick type C1 by detection of bile acid metabolites

Insulin dysregulation drives mitochondrial cholesterol metabolite accumulation: initiating hepatic toxicity in nonalcoholic fatty liver disease

Profiling of Urinary Glucuronidated Bile Acids across Age Groups

Coffee modulates insulin-hepatocyte nuclear factor-4α-Cyp7b1 pathway and reduces oxysterol-driven liver toxicity in a nonalcoholic fatty liver disease mouse model

Characterization of long-chain fatty acid-linked bile acids: a major conjugation form of 3β-hydroxy bile acids in feces

Fxr signaling and microbial metabolism of bile salts in the zebrafish intestine.

Berberine alters gut microbial function through modulation of bile acids

Berberine Prevents Disease Progression of Nonalcoholic Steatohepatitis through Modulating Multiple Pathways

Collaborators (5)

Saori Oguri

Jia Wen

Hisamitsu Hayashi

Rebecca Martin

Mitsuyoshi Suzuki

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