Hisamitsu Hayashi

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Associate Professor

University of Tokyo

Japan

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Hisamitsu Hayashi is an Associate Professor at The University of Tokyo, Japan. His research focuses on cholestasis-related genetic disorders, bile acid metabolism, and the clinical management of liver diseases in pediatric populations. Recent publications include studies on lipoprotein receptor gene variants in familial intrahepatic cholestasis and the use of human iPSC-derived hepatocyte models for research on cholestatic conditions.

Recent Grants

Grant: Close

健康長寿社会の実現に資する革新的低コスト医療創製基盤の構築

Open Date: 2021-07-09

Close Date: 2024-03-31

Grant: Close

生物情報学、発生医学の活用による原因不明小児肝臓難病の病態発症分子基盤の解明

Open Date: 2020-10-27

Close Date: 2023-03-31

Grant: Close

ABC輸送体の機能増強による疾患治療実現に向けた創薬標的の同定法開発

Open Date: 2020-04-01

Close Date: 2023-03-31

Grant: Close

Development of novel diagnostic method for refractory pediatric liver diseases

Open Date: 2018-06-29

Close Date: 2021-03-31

Grant: Close

Development of a strategy of drug development for ABC transporter-related diseases

Open Date: 2017-04-01

Close Date: 2020-03-31

Articles (14)

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2020

Collaborators (10)

Yoshiki Miura

Juntendo University

JAPAN

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Tadahaya Mizuno

assistant professor

University of Tokyo

JAPAN

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Genta Kakiyama

Associate Professor

University of Virginia School of Medicine

UNITED STATES

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Sheikh Tamir Rashid

Clinical Reader

Imperial College London

UNITED KINGDOM

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Chris Mayhew

Associate Professor

Cincinnati Children's Hospital Medical Center

UNITED STATES

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Saori Oguri

Oita University Hospital

JAPAN

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Takahisa Nakamura

Associate Professor

Cincinnati Children's Hospital Medical Center

UNITED STATES

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Yueh-Chiang Hu

Associate Professor/Director of Transgenic Animal and Genome Editing Core

Cincinnati Children's Hospital Medical Center

UNITED STATES

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Davide Danovi

King’s College London

UNITED KINGDOM

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Tatsuki Mizuochi

Kurume University School of Medicine

JAPAN

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Hisamitsu Hayashi

Research Interests

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About

Recent Grants

Articles (14)

Lipolysis‐Stimulated Lipoprotein Receptor Gene Variants as a Cause of Progressive Familial Intrahepatic Cholestasis: A Case Report

Rapid in vivo evaluation system for cholestasis-related genes in mice with humanized bile acid profiles

Clinicopathologic Features, Genetics, Treatment, and Long-Term Outcomes in Japanese Children and Young Adults with Benign Recurrent Intrahepatic Cholestasis: A Multicenter Study

Dried blood spot-based newborn screening for bile acid synthesis disorders, Zellweger spectrum disorder, and Niemann-Pick type C1 by detection of bile acid metabolites

Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis

Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiency.

Clinical and genetic features of congenital bile acid synthesis defect with a novel mutation in AKR1D1 gene sequencing: Case reports

Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation.

A randomized trial to examine the impact of food on pharmacokinetics of 4-phenylbutyrate and change in amino acid availability after a single oral administration of sodium 4-phenylbutyrarte in healthy volunteers

Influence of food on pharmacokinetics and pharmacodynamics of 4-phenylbutyrate in patients with urea cycle disorders

Long-term Outcomes of Living-donor Liver Transplantation for Progressive Familial Intrahepatic Cholestasis Type 1

Long-Term Outcomes of Living-Donor Liver Transplantation for Progressive Familial Intrahepatic Cholestasis Type 1.

Assessment of Adenosine Triphosphatase Phospholipid Transporting 8B1 (ATP8B1) Function in Patients With Cholestasis With ATP8B1 Deficiency by Using Peripheral Blood Monocyte‐Derived Macrophages

Proposal of a liver histology-based scoring system for bile salt export pump deficiency.

Collaborators (10)

Yoshiki Miura

Tadahaya Mizuno

Genta Kakiyama

Sheikh Tamir Rashid

Chris Mayhew

Saori Oguri

Takahisa Nakamura

Yueh-Chiang Hu

Davide Danovi

Tatsuki Mizuochi

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