George Tofaris

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University of Oxford

United Kingdom

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Recent Grants

Grant: Open

Developing a mechanistic rationale for alpha-synuclein targeting therapies in Parkinson's disease

Open Date: 2021-11-01

Close Date: 2026-11-01

Grant: Close

Electrochemical detection of exosomal alpha-synuclein in Parkinson’s disease

Open Date: 2018-03-01

Close Date: 2021-08-01

Grant: Close

Inhibiting Misfolded Protein Propagation in Neurodegenerative Diseases

Open Date: 2017-03-01

Close Date: 2021-03-01

Grant: Close

Development of small molecule Usp8 inhibitors as therapeutics in Lewy body dementia

Open Date: 2015-10-01

Close Date: 2018-09-30

Grant: Close

Multimarker Parkinson's Diagnotic test kit for monitoring disease progression based on electroanalytical detection of protein changes in blood.

Open Date: 2015-01-19

Close Date: 2018-07-26

Articles (12)

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2024

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2024

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2022

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2021

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2021

Collaborators (14)

Meena Balasubramanian

Associate Professor of Computational Genomics

University of Oxford

UNITED KINGDOM

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Roman Fischer

Head of Advanced Proteomics Facility/Associate Professor

University of Oxford

UNITED KINGDOM

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Chrystalina A. Antoniades

UNITED KINGDOM

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Marc Wolf

Klinikum Stuttgart

GERMANY

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George Tofaris

Research Interests

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Recent Grants

Articles (12)

Detailed Analysis of ITPR1 Missense Variants Guides Diagnostics and Therapeutic Design

Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease

Monitoring α-synuclein ubiquitination dynamics reveals key endosomal effectors mediating its trafficking and degradation

Methodological considerations in neuronal extracellular vesicle isolation for α-synuclein biomarkers

Alternating Magnetic Field-Promoted Nanoparticle Mixing: The On-Chip Immunocapture of Serum Neuronal Exosomes for Parkinson’s Disease Diagnostics

Multiplexed Profiling of Extracellular Vesicles for Biomarker Development

Heterozygous UCHL1 loss-of-function variants cause a neurodegenerative disorder with spasticity, ataxia, neuropathy, and optic atrophy

The Phenotypic Continuum of ATP1A3-Related Disorders

Initiation and progression of α-synuclein pathology in Parkinson’s disease

Longitudinal changes of early motor and cognitive symptoms in progressive supranuclear palsy: the OxQUIP study

Validation of α-Synuclein in L1CAM-Immunocaptured Exosomes as a Biomarker for the Stratification of Parkinsonian Syndromes.

Phenotypic manifestation of α-synuclein strains derived from Parkinson’s disease and multiple system atrophy in human dopaminergic neurons

Collaborators (14)

Meena Balasubramanian

Andrew Castle

Simon McGowan

Santosh Mordekar

Michele Hu

Jason Davis

Sally Ann Lynch

Cheng Jiang

Mohamed Sharafeldin

Ying Fu

David Sims

Roman Fischer

Chrystalina A. Antoniades

Marc Wolf

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