Georges Leclercq

Prof. Dr.

Universiteit Gent

Belgium

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About

Prof. Dr. Georges Leclercq is a faculty member at Universiteit Gent in Belgium. His research primarily focuses on natural killer (NK) cell development and functionality, as well as T cell dynamics and regulation. Recent articles explore topics such as the role of transcription factors in immune cell generation and the implications of gene variants in immune responses.

Articles (10)

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2022

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2022

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2022

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2022

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2021

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2021

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2021

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2021

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2020

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2020

Collaborators (7)

Lore Billiet

Ghent University

BELGIUM

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Tom Taghon

Professor at Ghent University

Ghent University

BELGIUM

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Bart Vandekerckhove

BELGIUM

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Kai Ling Liang

Postdoctoral Researcher (Professor Tom Taghon's Laboratory)

Universiteit Gent

BELGIUM

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Filip Matthijssens

Ghent University

BELGIUM

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Francis Impens

Associate Professor

Ghent University

BELGIUM

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Pieter Van Vlierberghe

Ghent University

BELGIUM

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Georges Leclercq

Research Interests

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Articles (10)

The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency

Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregates

TXNIP Promotes Human NK Cell Development but Is Dispensable for NK Cell Functionality

Transcriptional dynamics and epigenetic regulation of E and ID protein encoding genes during human T cell development

Small-scale manufacturing of neoantigen-encoding messenger RNA for early-phase clinical trials

T-BET and EOMES Accelerate and Enhance Functional Differentiation of Human Natural Killer Cells

A Novel Non-Coding Variant in DCLRE1C Results in Deregulated Splicing and Induces SCID Through the Generation of a Truncated ARTEMIS Protein That Fails to Support V(D)J Recombination and DNA Damage Repair

In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality

Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development

Human Thymic CD10<sup>+</sup> PD-1<sup>+</sup> Intraepithelial Lymphocyte Precursors Acquire Interleukin-15 Responsiveness at the CD1a<sup>–</sup> CD95<sup>+</sup> CD28<sup>–</sup> CCR7<sup>–</sup> Developmental Stage

Collaborators (7)

Lore Billiet

Tom Taghon

Bart Vandekerckhove

Kai Ling Liang

Filip Matthijssens

Francis Impens

Pieter Van Vlierberghe

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