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Gerald Schwank

Associate Professor

University of Zurich

Switzerland

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Research Interests

Cell Biology

60%

Biochemical Engineering

30%

Genome Engineering

40%

Genome Editing

40%

Cancer Biology

30%

Mutagenesis

30%

Crispr/cas9

20%

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Recent Grants

Grant: Close

High-Sensitivity Fluorescence/Luminescence Plate Reader system for in vitro screening applications

Open Date: 2021-12-01

Close Date: 2022-11-30

Grant: Close

Establishment of in vivo CRISPR-Cas base editor approaches to treat monogenetic liver diseases

Open Date: 2019-04-01

Close Date: 2023-03-31

Grant: Close

Patient-derived glial precursor cell therapy for vanishing white matter disease

Open Date: 2016-11-01

Close Date: 2018-10-31

Grant: Close

CRISPR/Cas9 genome-editing in stem cell organoids to functionally characterize regulators of tissue homeostasis and tumor driver genes

Open Date: 2015-04-01

Close Date: 2018-03-31

Grant: Close

Defining the mechanisms regulating intestinal homeostasis

Open Date: 2012-05-01

Close Date: 2015-04-30

Articles22

Treatment of a metabolic liver disease in mice with a transient prime editing approach.

Article Link

Year:

2025

Predicting adenine base editing efficiencies in different cellular contexts by deep learning.

Article Link

Year:

2025

Strategies for Interdisciplinary Human Gene Editing Research: Insights from a Swiss Project.

Article Link

Year:

2025

In vivo base editing of a pathogenic Eif2b5 variant improves vanishing white matter phenotypes in mice.

Article Link

Year:

2024

Enhancing prime editor activity by directed protein evolution in yeast.

Article Link

Year:

2024

Continuous directed evolution of a compact CjCas9 variant with broad PAM compatibility

Article Link

Year:

2024

Therapeutic liver cell transplantation to treat murine PKU

Article Link

Year:

2024

Effective genome editing with an enhanced ISDra2 TnpB system and deep learning-predicted ωRNAs.

Article Link

Year:

2024

Machine learning prediction of prime editing efficiency across diverse chromatin contexts.

Article Link

Year:

2024

Base editing of Ptbp1 in neurons alleviates symptoms in a mouse model of Parkinson's disease.

Article Link

Year:

2024

Targeted knock-in of NCF1 cDNA into the NCF2 locus leads to myeloid phenotypic correction of p47 phox -deficient chronic granulomatous disease.

Article Link

Year:

2024

Predicting prime editing efficiency and product purity by deep learning

Article Link

Year:

2023

Mutant SF3B1 promotes malignancy in PDAC.

Article Link

Year:

2023

Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing.

Article Link

Year:

2022

In vivo prime editing of a metabolic liver disease in mice.

Article Link

Year:

2022

SF3B1 facilitates HIF1-signaling and promotes malignancy in pancreatic cancer.

Article Link

Year:

2022

Drug screening and genome editing in human pancreatic cancer organoids identifies drug-gene interactions and candidates for off-label treatment.

Article Link

Year:

2022

In vivo targeting of a variant causing vanishing white matter using CRISPR/Cas9

Article Link

Year:

2022

miR-802 Suppresses Acinar-to-Ductal Reprogramming During Early Pancreatitis and Pancreatic Carcinogenesis

Article Link

Year:

2022

Identification of HIF-dependent alternative splicing in gastrointestinal cancers and characterization of a long, coding isoform of SLC35A3

Article Link

Year:

2021

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

Article Link

Year:

2021

In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA

Article Link

Year:

2021

Collaborators19

Niek van Til

Assistant professor

Amsterdam UMC Locatie VUmc

NETHERLANDS

Lucas Kissling

University of Zurich

SWITZERLAND

Vivi Heine

Associate Professor

University of Amsterdam

NETHERLANDS

Zacharias Kontarakis

Head of GEML

Eidgenössische Technische Hochschule Zürich

SWITZERLAND

Hiu Man Grisch-Chan

University of Zurich

SWITZERLAND

Matthias Peter

Professor at the Institute of Biochemistry

ETH-Bereich Hochschulen

SWITZERLAND

Martin Jinek

Associate Professor

University of Zurich

SWITZERLAND

Michael Krauthammer

Professor

University of Zurich

SWITZERLAND

Manfred Kopf

Professor

ETH Zürich

SWITZERLAND

B Leeners

University Hospital of Zurich

SWITZERLAND

Marjo S van der Knaap

Amsterdam University Medical Centers

NETHERLANDS

Lukas Schmidheini

ETH Zurich

SWITZERLAND

Kevin Holden

Head of Science & Applied Research

UNITED STATES

Ute Modlich

Research Laboratory Head

University of Zurich

SWITZERLAND

Janine Reichenbach

Head Division of Somatic Gene Therapy

University Children's Hospital Zurich

SWITZERLAND

giovanni pellegrini

VP Head of Pathology

ITALY

Yuliang He

ETH Zürich

SWITZERLAND

Masako Monika Kaufmann

University Medical Center Freiburg

GERMANY

Markus Stoffel

Professor

ETH Zürich

SWITZERLAND

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Gerald Schwank

Associate Professor

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Research Interests

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Recent Grants

Articles22

Treatment of a metabolic liver disease in mice with a transient prime editing approach.

Predicting adenine base editing efficiencies in different cellular contexts by deep learning.

Strategies for Interdisciplinary Human Gene Editing Research: Insights from a Swiss Project.

In vivo base editing of a pathogenic Eif2b5 variant improves vanishing white matter phenotypes in mice.

Enhancing prime editor activity by directed protein evolution in yeast.

Continuous directed evolution of a compact CjCas9 variant with broad PAM compatibility

Therapeutic liver cell transplantation to treat murine PKU

Effective genome editing with an enhanced ISDra2 TnpB system and deep learning-predicted ωRNAs.

Machine learning prediction of prime editing efficiency across diverse chromatin contexts.

Base editing of <i>Ptbp1</i> in neurons alleviates symptoms in a mouse model of Parkinson's disease.

Targeted knock-in of <i>NCF1</i> cDNA into the <i>NCF2</i> locus leads to myeloid phenotypic correction of p47 <sup><i>phox</i></sup> -deficient chronic granulomatous disease.

Predicting prime editing efficiency and product purity by deep learning

Mutant SF3B1 promotes malignancy in PDAC.

Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing.

In vivo prime editing of a metabolic liver disease in mice.

SF3B1 facilitates HIF1-signaling and promotes malignancy in pancreatic cancer.

Drug screening and genome editing in human pancreatic cancer organoids identifies drug-gene interactions and candidates for off-label treatment.

In vivo targeting of a variant causing vanishing white matter using CRISPR/Cas9

miR-802 Suppresses Acinar-to-Ductal Reprogramming During Early Pancreatitis and Pancreatic Carcinogenesis

Identification of HIF-dependent alternative splicing in gastrointestinal cancers and characterization of a long, coding isoform of SLC35A3

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA

Collaborators19

Niek van Til

Lucas Kissling

Vivi Heine

Zacharias Kontarakis

Hiu Man Grisch-Chan

Matthias Peter

Martin Jinek

Michael Krauthammer

Manfred Kopf

B Leeners

Marjo S van der Knaap

Lukas Schmidheini

Kevin Holden

Ute Modlich

Janine Reichenbach

giovanni pellegrini

Yuliang He

Masako Monika Kaufmann

Markus Stoffel

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