Gilles van Wezel

Professor of Molecular Biotechnology

Leiden University

Netherlands

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About

Gilles van Wezel is a Professor of Molecular Biotechnology at Leiden University in the Netherlands. His research focuses on the biosynthesis of natural products, regulatory gene networks, and the discovery of novel metabolites in bacteria. Recent articles highlight his work on biosynthetic gene clusters in Streptomyces, novel biosynthetic pathways, and innovative approaches for antibiotic discovery through ecology and machine learning.

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2022

Collaborators (15)

Dennis Claessen

Professor of Molecular Microbiology

Leiden University

NETHERLANDS

Gilles van Wezel

Research Interests

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Articles (20)

Biomimetic Total Synthesis and Paired Omics Identify an Intermolecular Diels–Alder Reaction as the Key Step in Lugdunomycin Biosynthesis

Exploring the Chemical Space of Paenibacillus NRPs and Discovery of Paenilipoheptin B

Regulatory Genes as Beacons for Discovery and Prioritization of Biosynthetic Gene Clusters in Streptomyces

Genome mining based on transcriptional regulatory networks uncovers a novel locus involved in desferrioxamine biosynthesis

Total Synthesis, Structure Elucidation, and Bioactivity Evaluation of the Cyclic Lipopeptide Natural Product Paenilipoheptin A

The stomatin-like protein StlP organizes membrane microdomains to govern polar growth in filamentous actinobacteria under hyperosmotic stress

New solutions for antibiotic discovery: Prioritizing microbial biosynthetic space using ecology and machine learning

Divergence of Classical and C-Ring-Cleaved Angucyclines: Elucidation of Early Tailoring Steps in Lugdunomycin and Thioangucycline Biosynthesis

Polyester degradation by soil bacteria: identification of conserved BHETase enzymes in Streptomyces

nanoRAPIDS as an analytical pipeline for the discovery of novel bioactive metabolites in complex culture extracts at the nanoscale

Total Synthesis and Structure Assignment of the Relacidine Lipopeptide Antibiotics and Preparation of Analogues with Enhanced Stability

The SepF-like proteins SflA and SflB prevent ectopic localization of FtsZ and DivIVA during sporulation of Streptomyces coelicolor

Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA

FtsZ phosphorylation pleiotropically affects Z-ladder formation, antibiotic production, and morphogenesis in Streptomyces coelicolor

A BioBricks Metabolic Engineering Platform for the Biosynthesis of Anthracyclinones in Streptomyces coelicolor

Endocytosis-like DNA uptake by cell wall-deficient bacteria

System-Wide Analysis of the GATC-Binding Nucleoid-Associated Protein Gbn and Its Impact on Streptomyces Development

Role for a Lytic Polysaccharide Monooxygenase in Cell Wall Remodeling in Streptomyces coelicolor

The ubiquitous catechol moiety elicits siderophore and angucycline production in Streptomyces

Anthracyclines: biosynthesis, engineering and clinical applications

Collaborators (15)

Dennis Claessen

Han de Winde

Marnix H. Medema

Mikko Metsä-Ketelä

Arthur Ram

Remco Havenith

Eric Nybo

Adriaan Minnaard

Angel Manteca-Fernandez

Somayah Elsayed

Joost Willemse

Ana V. Cunha

Mark Liles

Nathaniel I. Martin

Alexander Kros

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