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Giulia Escobar

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Principal Investigator at the Cellular Immunotherapy Center

Massachusetts General Hospital

United States

Research Interests

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Professors in United States Professors in Immunology Immunology professors in United States

Recent Grants

Grant: Open

Armored CAR-T cells to treat TNBC and boost host immunity

Open Date: 2025-07-01

Close Date: 2027-06-01

Grant: Close

lnvestigating the role of stem-like CD8+ T cells in cancer immunotherapy

Open Date: 2020-07-01

Close Date: 2023-06-01

Grant: Close

Investigating TCF1-mediated regulation of PD1-Tim3- tumor-infiltrating CD8+ T lymphocytes and their role in immunotherapy

Open Date: 2018-07-01

Close Date: 2020-06-01

Articles (19)

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Harvard University

UNITED STATES

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Laura Cox

Assistant Professor

Brigham and Women's Hospital and Harvard Medical School

UNITED STATES

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Giulia Escobar

Research Interests

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Recent Grants

Articles (19)

Ruxolitinib for Ciltacabtagene Autoleucel-Associated Refractory Diarrhea.

Gene regulatory elements determine efficacy of BCMA-targeted CAR-T cell products

Ibrutinib and PD-1 Blockade Potentiate Mesothelin-Targeting CAR T-cell Therapy in Preclinical Models of Pancreatic Cancer

Rational Engineering of Notch1 Signaling to Boost the Proliferation of CD19-BBζ CAR-T

Optimizing CAR T cell therapy in pancreatic cancer through clinically actionable combinations

IFN-γ-resistant CD28 CAR T cells demonstrate increased survival, efficacy, and durability in multiple murine tumor models.

CD70 CAR T cells secreting an anti-CD33/anti-CD3 dual-targeting antibody overcome antigen heterogeneity in AML.

Tuning CAR-T cells by targeting cancer-associated glycan in pancreatic cancer

CAR-T cell therapy targeting MUC17 in gastric tumors

Tandem CAR-T cells targeting mesothelin and MUC16 overcome tumor heterogeneity by targeting one antigen at a time

Secretion of a VEGF-Blocking scFv Enhances CAR T-cell Potency

On-target off-tumor toxicity of claudin18.2-directed CAR-T cells in preclinical models

In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma

CAR-T cells in solid tumors: Challenges and breakthroughs.

Dietary protein modulates intestinal dendritic cells to establish mucosal homeostasis.

Decoding T cell state-specific regulomes in cancer

Transcription factor TCF1 binds to RORγt and orchestrates a regulatory network that determines homeostatic Th17 cell state.

Pan-cancer mapping of single CD8+ T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity

Tumor immunogenicity dictates reliance on TCF1 in CD8+ T cells for response to immunotherapy

Collaborators (11)

Filippo Birocchi

Millicent Ekwudo

Luke Schwerdtfeger

Davide Mangani

Nicholas Haradhvala

Shirong Liu

Charlotte Graham

Ana Anderson

Raymond Sobel

Sangwoo Park

Laura Cox

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