Grahame Hardie

Professor of Cellular Signalling

University of Dundee

United Kingdom

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Professor Grahame Hardie is a distinguished faculty member at the University of Dundee, UK. His research focuses on cellular signaling mechanisms, particularly involving the AMP-activated protein kinase (AMPK), with recent articles exploring its role in cancer biology, lysosomal and mitochondrial biogenesis, and guanine nucleotide exchange factors. His work contributes significantly to our understanding of AMPK activation and function, and its implications in various physiological and pathological contexts.

Articles (14)

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2024

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2020

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2020

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2020

Collaborators (4)

Andrew Holmes

Lecturer in Cardiac and Respiratory Physiology

University of Birmingham

UNITED KINGDOM

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Sreenivasan Ponnambalam

Reader in Human Disease Biology

University of Leeds

UNITED KINGDOM

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Mark Dallas

Associate Professor in Cellular Neuroscience

University of Reading

UNITED KINGDOM

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Alessio Ciulli

Professor

University of Dundee

UNITED KINGDOM

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Grahame Hardie

Research Interests

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Articles (14)

The pro-drug C13 activates AMPK by two distinct mechanisms

AMP-activated protein kinase can be allosterically activated by ADP but AMP remains the key activating ligand

AMPK associates with and causes fragmentation of the Golgi by phosphorylating the guanine nucleotide exchange factor GBF1

AMPK promotes lysosomal and mitochondrial biogenesis via folliculin:FNIP1

New insights into activation and function of the AMPK

BAY-3827 and SBI-0206965: Potent AMPK Inhibitors That Paradoxically Increase Thr172 Phosphorylation

Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers

LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory response.

Publisher Correction: LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory response

100 years of the Warburg effect: a historical perspective

AMP-activated protein kinase — a journey from 1 to 100 downstream targets

AMP-Activated Protein Kinase: Do We Need Activators or Inhibitors to Treat or Prevent Cancer?

AMPK as a direct sensor of long-chain fatty acyl–CoA esters

AMPK and the Need to Breathe and Feed: What’s the Matter with Oxygen?

Collaborators (4)

Andrew Holmes

Sreenivasan Ponnambalam

Mark Dallas

Alessio Ciulli

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