Sreenivasan Ponnambalam

Reader in Human Disease Biology

University of Leeds

United Kingdom

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Dr. Sreenivasan Ponnambalam is a Reader in Human Disease Biology at the University of Leeds, UK. His research focuses on the intersections of cancer and cardiovascular diseases, featuring topics such as lipid particle recognition in atherosclerosis, the roles of MDM2 and MDM4, and the application of Affimer technology. He is also involved in computational approaches to drug discovery for infectious diseases and the development of practical applications in cell biology for educational programs.

Articles (17)

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2025

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2020

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2020

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2020

Collaborators (8)

William Critchley

Research Fellow

University of Leeds

UNITED KINGDOM

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Grahame Hardie

Professor of Cellular Signalling

University of Dundee

UNITED KINGDOM

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Queen Saikia

University of Leeds

UNITED KINGDOM

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Shervanthi Homer-Vanniasinkam

University College London

UNITED KINGDOM

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Cedric Duval

Lecturer

University of Leeds

UNITED KINGDOM

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Stephen Muench

Lecturer in Membrane Biology

University of Leeds

UNITED KINGDOM

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Nikoletta Pechlivani

University of Leeds

UNITED KINGDOM

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Katie Simmons

University of Leeds

UNITED KINGDOM

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Sreenivasan Ponnambalam

Research Interests

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About

Articles (17)

Use of Affimer Technology for Inhibition of α2-antiplasmin and Enhancement of Fibrinolysis

Structure and function of MDM2 and MDM4 in health and disease

Modified Lipid Particle Recognition: A Link Between Atherosclerosis and Cancer?

AMPK associates with and causes fragmentation of the Golgi by phosphorylating the guanine nucleotide exchange factor GBF1

The E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2D2 regulate VEGFR2 dynamics and endothelial function

“Affimer” synthetic protein scaffolds block oxidized LDL binding to the LOX-1 scavenger receptor and inhibit ERK1/2 activation

Identification of FDA-approved drugs against SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) through computational virtual screening

A research-led flexible cell biology practical for biological sciences undergraduate and postgraduate degree courses

Homology modelling and molecular simulation approach to prediction of B-cell and T-cell epitopes in an OMP25 peptide vaccine against Brucella abortus

In-silico prediction, characterization, molecular docking and dynamic simulation studies for screening potential fungicides against leaf rust of Triticum aestivum

Virtual high throughput screening of natural peptides against ErbB1 and ErbB2 to identify potential inhibitors for cancer chemotherapy

Affinity purification of fibrinogen using an Affimer column

TDO2 modulates liver cancer cell migration and invasion via the Wnt5a pathway

Prognostic Value of Members of NFAT Family For Pan-Cancer and a Prediction Model Based on NFAT2 in Bladder Cancer

Structural Basis for Vascular Endothelial Growth Factor Receptor Activation and Implications for Disease Therapy

Scavenger Receptors as Biomarkers and Therapeutic Targets in Cardiovascular Disease

ATF-2 and Tpl2 regulation of endothelial cell cycle progression and apoptosis

Collaborators (8)

William Critchley

Grahame Hardie

Queen Saikia

Shervanthi Homer-Vanniasinkam

Cedric Duval

Stephen Muench

Nikoletta Pechlivani

Katie Simmons

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