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Gregory M. Cook

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University of Otago

New Zealand

Research Interests

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Recent Grants

Grant: Close

Waerau waikawa iti rongoā paturopi: New Generation Peptide Antibiotics

Open Date: 2020-10-01

Close Date: 2026-03-30

Grant: Close

Collaborative biomedical research programme with leading Chinese institutions

Open Date: 2020-06-30

Close Date: 2026-06-30

Grant: Close

Precision Antimicrobials: Targeted Therapeutics for Food and Companion Animal Infections

Open Date: 2019-10-01

Close Date: 2025-09-30

Grant: Close

TB or not TB - examining the origin and evolution of tuberculosis in the pre-European Pacific

Open Date: 2018-01-01

Close Date: 2021-01-01

Grant: Close

Unraveling the key role of cytochrome bd oxidase in antimicrobial lethality in tuberculosis

Open Date: 2017-01-01

Close Date: 2020-01-01

Articles (24)

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Collaborators (23)

Scott Ferguson

Senior Research Fellow

University of Otago

NEW ZEALAND

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Manuela Joerg

Senior Lecturer

Monash University Malaysia.

AUSTRALIA

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Jamie Blaza

Professor of Biophysics

University of York

UNITED KINGDOM

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Michael Boshart

Professor of Genetics

Ludwig-Maximilians-Universität München

GERMANY

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Sergio Morales

Associate Professor

University of Otago

NEW ZEALAND

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Richard J. Payne

Professor of Organic Chemistry and Chemical Biology and ARC Laureate Fellow

University of Sydney

AUSTRALIA

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Daniel Ken INAOKA

Professor

Nagasaki University

JAPAN

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Christoph von Ballmoos

Prof. Dr.

University of Bern

SWITZERLAND

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Nina Dickerhof

University of Otago Christchurch

NEW ZEALAND

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Yuichi Matsuo

Assistant Professor

Oita University

JAPAN

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Paul H. Edelstein

University of Pennsylvania

UNITED STATES

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Glen Carter

Senior Research Fellow

University of Melbourne

AUSTRALIA

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Scott McDougall

Professor

Massey University

NEW ZEALAND

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Daniel Pletzer

Associate Professor

University of Otago

NEW ZEALAND

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Amandeep Kaur

Lecturer and ARC DECRA Fellow

MONASH UNIVERSITY

AUSTRALIA

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Chris Greening

Professor

MONASH UNIVERSITY

AUSTRALIA

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Peter Brzezinski

Stockholm University

SWEDEN

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Shaun Lott

Associate Professor

University of Auckland

NEW ZEALAND

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Htin Lin Aung

University of Otago

NEW ZEALAND

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Matthew McNeil

Senior Research Fellow

University of Otago

NEW ZEALAND

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Veronika Sander

Senior Research Fellow

University of Auckland

NEW ZEALAND

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Rhys Grinter

Lab Head

University of Melbourne

AUSTRALIA

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John Rubinstein

Professor

University of Toronto

CANADA

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Gregory M. Cook

Research Interests

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Recent Grants

Articles (24)

Affinity-Based Proteome Profiling to Identify Targets of Tuberculosis Antibiotics

ATP synthesis driven by atmospheric hydrogen concentrations

Development of tolerance to bedaquiline by overexpression of trypanosomal acetate: succinate CoA transferase in Mycobacterium smegmatis.

Comparative genomics of endemic Staphylococcus aureus ST1 in New Zealand

Whole genome sequencing reveals novel resistance-conferring mutations and large genome deletions in drug-resistant Mycobacterium tuberculosis isolates from Indonesia

Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity

Cryo-EM of native membranes reveals an intimate connection between the Krebs cycle and aerobic respiration in mycobacteria

Remission spectroscopy resolves the mechanism of action of bedaquiline within living mycobacteria

Structure and assembly of the MmpL5/MmpS5 efflux transporter from Mycobacterium tuberculosis

ClpC1 Modulating Ohmyungsamycin A and Ecumicin Natural Product Analogues are Potent Antimycobacterials

Structure of Mycobacterial NDH-2 Bound to a 2-Mercapto-Quinazolinone Inhibitor

Allenamides as a Powerful Tool to Incorporate Diversity: Thia‐Michael Lipidation of Semisynthetic Peptides and Access to β‐Keto Amides

Phenotypic‐Based Discovery and Exploration of a Resorufin Scaffold with Activity against Mycobacterium tuberculosis

Allenamides as a Powerful Tool to Incorporate Diversity: Thia‐Michael Lipidation of Semisynthetic Peptides and Access to β‐Keto Amides

Blueprints for ATP machinery will aid tuberculosis drug design

The two‐component system CroRS acts as a master regulator of cell envelope homeostasis to confer antimicrobial tolerance in the bacterial pathogen Enterococcus faecalis

The evolution of antibiotic resistance is associated with collateral drug phenotypes in Mycobacterium tuberculosis

RNase HI Depletion Strongly Potentiates Cell Killing by Rifampicin in Mycobacteria

Complete Genome Sequence of a New Zealand Mycobacterium tuberculosis Strain Responsible for Ongoing Transmission over the Past 30 Years

Impaired Succinate Oxidation Prevents Growth and Influences Drug Susceptibility in Mycobacterium tuberculosis

<i>Mycobacterium smegmatis</i> Resists the Bactericidal Activity of Hypochlorous Acid Produced in Neutrophil Phagosomes.

CRISPR interference identifies vulnerable cellular pathways with bactericidal phenotypes in Mycobacterium tuberculosis

Disruption of Metallostasis in the Anaerobic Human Pathogen Fusobacterium nucleatum by the Zinc Ionophore PBT2

Discovery of a Natural Product That Binds to the <i>Mycobacterium tuberculosis</i> Protein Rv1466 Using Native Mass Spectrometry

Collaborators (23)

Scott Ferguson

Manuela Joerg

Jamie Blaza

Michael Boshart

Sergio Morales

Richard J. Payne

Daniel Ken INAOKA

Christoph von Ballmoos

Nina Dickerhof

Yuichi Matsuo

Paul H. Edelstein

Glen Carter

Scott McDougall

Daniel Pletzer

Amandeep Kaur

Chris Greening

Peter Brzezinski

Shaun Lott

Htin Lin Aung

Matthew McNeil

Veronika Sander

Rhys Grinter

John Rubinstein

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