Guillaume Médard

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Technical University of Munich

Germany

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Recent Grants

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Chemoproteomics-enabled proteome-wide screening applied to probe discovery (ChemProtScreen)

Open Date: 2022-01-01

Close Date:

Grant: Close

A toolbox of promiscuous immobilisation chemistries to identify the targets of natural compounds by chemoproteomics (PromisChemProt)

Open Date: 2021-01-01

Close Date:

Grant: Close

Establishing pharmacophore-centric proteome-wide structure-affinity relationships by chemical proteomics (ChemProtSAR)

Open Date: 2018-01-01

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Articles (13)

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2023

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2023

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2022

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2022

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2021

Collaborators (17)

Dany Pechalrieu

University of Chicago

UNITED STATES

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Wassim Gabriel

Technical University of Munich

GERMANY

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Volker Haucke

Director and Professor

Leibniz-Forschungsinstitut für Molekulare Pharmakologie

GERMANY

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Sonia SEVERIN

INSERM

FRANCE

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Mathias Wilhelm

Prof.

Technical University of Munich

GERMANY

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Bernhard Kuster

GERMANY

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Christian Grätz

Technical University of Munich

GERMANY

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Daniel Paul Zolg

Chief Operating Officer

GERMANY

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Haitham Hassan

Lecturer in Medicinal Chemistry & Drug Discovery

University of Sussex

UNITED KINGDOM

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Michael Pfaffl

Prof. of Molecular Physiolgy, Principal Invesitgator

Technical University of Munich

GERMANY

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Matthew The

KTH Royal Institute of Technology

SWEDEN

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Liliana Mancio Silva

Group leader

Institut Pasteur

FRANCE

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Jürgen Ruland

Technical University of Munich

GERMANY

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Mar Abril-Gil

GERMANY

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Patrick Leopold Rüther

Københavns Universitet

DENMARK

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Willi Auwärter

GERMANY

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Martin Klingenspor

Professor

Ludwig-Maximilians-Universität München

GERMANY

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Guillaume Médard

Research Interests

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Recent Grants

Articles (13)

Decrypting drug actions and protein modifications by dose- and time-resolved proteomics.

Chemoproteomic target deconvolution reveals Histone Deacetylases as targets of (R)-lipoic acid

Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum

Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors

Ricolinostat is not a highly selective HDAC6 inhibitor

Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition

Prosit-TMT: Deep Learning Boosts Identification of TMT-Labeled Peptides.

Development of selective inhibitors of phosphatidylinositol 3-kinase C2α.

Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target.

Merits of Diazirine Photo-Immobilization for Target Profiling of Natural Products and Cofactors

N-Heterocyclic Carbenes: Molecular Porters of Surface Mounted Ru-Porphyrins.

Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout

Assembly and Manipulation of a Prototypical N-Heterocyclic Carbene with a Metalloporphyrin Pedestal on a Solid Surface

Collaborators (17)

Dany Pechalrieu

Wassim Gabriel

Volker Haucke

Sonia SEVERIN

Mathias Wilhelm

Bernhard Kuster

Christian Grätz

Daniel Paul Zolg

Haitham Hassan

Michael Pfaffl

Matthew The

Liliana Mancio Silva

Jürgen Ruland

Mar Abril-Gil

Patrick Leopold Rüther

Willi Auwärter

Martin Klingenspor

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