Volker Haucke

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Director and Professor

Leibniz-Forschungsinstitut für Molekulare Pharmakologie

Germany

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Volker Haucke is the Director and Professor at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie in Germany. His research areas focus on cellular mechanisms involving clathrin interactions, neuronal autophagy, and lipid homeostasis, as highlighted in his recent publications. He has contributed to advancing the understanding of synaptic vesicle biogenesis and organelle junctions, alongside the roles of Rho GTPase signaling in endocytosis.

Recent Grants

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Mechanisms of Presynaptic Biogenesis and Dynamic Remodeling [SynapseBuild]

Open Date: 2020-12-01

Close Date: 2025-11-01

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Director, Professor of Physiology

Christian-Albrechts-Universität zu Kiel

GERMANY

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Martin Lehmann

Head of Cellular Imaging Core Facility

Leibniz-Forschungsinstitut für Molekulare Pharmakologie

GERMANY

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Jörg Piontek

GERMANY

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Jocelyn Laporte

University of Strasbourg

FRANCE

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Philipp Alexander Koch

Leibniz-Forschungsinstitut für Molekulare Pharmakologie

GERMANY

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Volker Haucke

Research Interests

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Recent Grants

Articles (23)

Front Cover: Inhibition of the Clathrin Terminal Domain—Amphiphysin Protein–Protein Interaction. Probing the Pitstop 2 Aromatic Moiety (ChemMedChem 16/2025)

Inhibition of the Clathrin Terminal Domain—Amphiphysin Protein–Protein Interaction. Probing the Pitstop 2 Aromatic Moiety

Neuronal autophagy controls excitability via ryanodine receptor–mediated regulation of calcium-activated potassium channel function

Mechanisms and functions of lysosomal lipid homeostasis

Canonical and non-canonical integrin-based adhesions dynamically interconvert

A three-way organelle junction controls PI(4)P metabolism and mitochondrial division

Phosphoinositide detection at synapses of fixed murine hippocampal neurons

Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

ER remodeling via lipid metabolism

Biogenesis and reformation of synaptic vesicles

Orchestrating vesicular and nonvesicular membrane dynamics by intrinsically disordered proteins

Intersectin deficiency impairs cortico-striatal neurotransmission and causes obsessive–compulsive behaviors in mice

The Autophagy Nucleation Factor ATG9 Forms Nanoclusters with the HIV-1 Receptor DC-SIGN and Regulates Early Antiviral Autophagy in Human Dendritic Cells

NMDA-receptor-Fc-fusion constructs neutralize anti-NMDA receptor antibodies.

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

Antagonistic control of active surface integrins by myotubularin and phosphatidylinositol 3-kinase C2β in a myotubular myopathy model

Nanoscale segregation of channel and barrier claudins enables paracellular ion flux

Endosomal lipid signaling reshapes the endoplasmic reticulum to control mitochondrial function.

Phosphoinositides as membrane organizers

The molecular organization of differentially curved caveolae indicates bendable structural units at the plasma membrane

Development of selective inhibitors of phosphatidylinositol 3-kinase C2α.

Collaborators (14)

Christopher Schmied

Sonia SEVERIN

Christian Geis

Tanja Maritzen

Guillaume Médard

Phillip J. Robinson

Stefan Hallermann

Dorothee Günzel

Fabien P. Blanchet

Markus Bleich

Martin Lehmann

Jörg Piontek

Jocelyn Laporte

Philipp Alexander Koch

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