Gyochang Keum

Professor

University of Science and Technology (UST)

South Korea

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Professor Gyochang Keum is affiliated with the University of Science and Technology (UST) in South Korea. His research areas include the development of novel anticancer agents, specifically targeting carbonic anhydrases and B-RAF kinases, as well as exploring selective inhibitors for discoidin domain receptors. He has recently published articles on immunological responses to vaccine sequences and the medicinal chemistry of various compounds aimed at overcoming drug resistance in cancer therapy.

Articles (12)

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2025

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2024

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2023

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2023

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2023

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2023

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2023

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2023

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2023

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2023

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2022

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2021

Collaborators (2)

Claudiu T Supuran

University of Florence

ITALY

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Soyeon Yoo

University of Pennsylvania

UNITED STATES

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Gyochang Keum

Research Interests

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Articles (12)

Novel N-(3-(1-(4-sulfamoylphenyl)triazol-4-yl)phenyl)benzamide Derivatives as Potent Carbonic Anhydrase Inhibitors with Broad-Spectrum Anticancer Activity: Leveraging Tail and Dual-Tail Approaches

Identification of Ureidocoumarin-Based Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors via Drug Repurposing Approach, Biological Evaluation, and In Silico Studies

Analyzing immune responses to varied mRNA and protein vaccine sequences

Design and Synthesis of New 4-(3,4,5-Trimethoxyphenyl)Thiazole-Pyrimidine Derivatives as Potential Antiproliferative Agents

Discovery of 3-((3-amino-<i>1H</i>-indazol-4-yl)ethynyl)-<i>N</i>-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide (AKE-72), a potent Pan-BCR-ABL inhibitor including the T315I gatekeeper resistant mutant

Discovery of New Quinolone-Based Diarylamides as Potent B-RAF<sup>V600E</sup>/C-RAF Kinase Inhibitors Endowed with Promising In Vitro Anticancer Activity

Discovery of new 6-ureido/amidocoumarins as highly potent and selective inhibitors for the tumour-relevant carbonic anhydrases IX and XII

Identification of New <i>N</i>-methyl-piperazine Chalcones as Dual MAO-B/AChE Inhibitors

Overcoming the imatinib-resistant BCR-ABL mutants with new ureidobenzothiazole chemotypes endowed with potent and broad-spectrum anticancer activity

Sinapic Acid Attenuates the Neuroinflammatory Response by Targeting AKT and MAPK in LPS-Activated Microglial Models

Metal/catalyst-free sequential C–N bond forming cascades at room temperature: environment-friendly one-pot synthesis of 5-aminoimidazoles from aryl glyoxals, anilines, and amidines

Scanning Electron Microscopy Morphology of Metal Salts of Saturated Aliphatic Acids: Sodium Ion Results Branched Fibrous Image

Collaborators (2)

Claudiu T Supuran

Soyeon Yoo

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