H. Leighton Grimes

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Professor

Cincinnati Children's Hospital Medical Center

United States

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About

H. Leighton Grimes is a Professor at Cincinnati Children's Hospital Medical Center in the United States. His research primarily focuses on the regulatory dynamics of splicing in leukemias, the roles of neutrophils in health and disease, and the genomics of hematopoietic progenitors. He has contributed significantly to understanding the implications of gestational diabetes on offspring health and factors influencing survival in acute myeloid leukemia.

Recent Grants

Grant: Close

Infectious pressures on cell competition and cooperation during leukemia initiation

Open Date: 2021-05-01

Close Date: 2023-04-01

Grant: Close

Modeling myelodysplasia

Open Date: 2021-01-01

Close Date: 2025-12-01

Grant: Close

A generalizable framework for linking single-cell genomic states with cell fate outcomes in hematopoiesis

Open Date: 2020-08-01

Close Date: 2025-05-01

Grant: Close

Regulation of functionally discrete hematopoietic stem cells

Open Date: 2020-03-01

Close Date: 2023-12-01

Grant: Close

Mechanisms of granulocyte homeostasis

Open Date: 2015-07-01

Close Date: 2024-04-01

Articles (21)

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2020

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2020

Collaborators (21)

S. Stephen Yi

University of Texas at Austin

UNITED STATES

H. Leighton Grimes

Research Interests

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About

Recent Grants

Articles (21)

Splicing regulatory dynamics for precision analysis and treatment of heterogenous leukemias

Deciphering the impact of genomic variation on function.

Splicing neoantigen discovery with SNAF reveals shared targets for cancer immunotherapy

Gestational diabetes in mice induces hematopoietic memory that affects the long-term health of the offspring

Gestational diabetes in mice induces hematopoietic memory that affects the long-term health of the offspring.

Resilient anatomy and local plasticity of naive and stress haematopoiesis

Multiomic profiling identifies predictors of survival in African American patients with acute myeloid leukemia

Sex-associated differences in frequencies and prognostic impact of recurrent genetic alterations in adult acute myeloid leukemia (Alliance, AMLCG)

The diverse roles of neutrophils from protection to pathogenesis

An immunophenotype-coupled transcriptomic atlas of human hematopoietic progenitors

Decision level integration of unimodal and multimodal single cell data with scTriangulate

pyInfinityFlow: optimized imputation and analysis of high-dimensional flow cytometry data for millions of cells

Improved detection of measurable residual disease in acute myeloid leukemia

Slow cycling and durable Flt3+ progenitors contribute to hematopoiesis under native conditions.

Induced cell-autonomous neutropenia systemically perturbs hematopoiesis in Cebpa enhancer-null mice

Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor.

Mouse models of neutropenia reveal progenitor-stage-specific defects.

SWATH-Proteomics of Ibrutinib's Action in Myeloid Leukemia Initiating Mutated G-CSFR Signaling.

Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition.

Unraveling bone marrow architecture

HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms.

Collaborators (21)

S. Stephen Yi

richard james

James Blachly

Daniel Starczynowski

Surya Prasath

Harinder Singh

Yihan Wang

Tamara Tilburgs

Angelo Taglialatela

Jeffrey Tyner

Daniel Lucas Alcaraz

I-hsin Su

Damien Reynaud

Jesse Engreitz

Jian Ma

Beatrice Borsari

Maarten Fornerod

Deedra Nicolet

Maximilien Evrard

Yun Li

Jasmine Sakr

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