Hans-Joachim Lehmler

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The University of Iowa

United States

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Recent Grants

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PCB Enantiomers Implicated in Neurodevelopmental Disorders: Identification of Individual Metabolic Factors that Determine Risk and Vulnerability

Open Date: 2017-09-01

Close Date: 2019-08-31

Grant: Close

SusChEM: Collaborative Research: Environmental Fate and Effects of Dichloroacetamide Safeners: An Overlooked Class of Emerging Contaminants?

Open Date: 2017-09-01

Close Date: 2020-08-31

Grant: Close

MRI: Acquisition of Instrumentation (LC-MS/MS) for the Trace Analysis of Anthropogenic Organic Compounds and Their Metabolites in Various Complex Matrices

Open Date: 2012-09-01

Close Date: 2013-08-31

Grant: Close

MRI: Acquisition of Instrumentation (LC-MS/MS) for the Trace Analysis of Anthropogenic Organic Compounds and Their Metabolites in Various Complex Matrices

Open Date: 2012-09-01

Close Date: 2013-08-31

Grant: Close

Collaborative Research: Design of Templated Ceramic Materials for Separation and Purification of Complex Carbohydrates

Open Date: 2010-05-15

Close Date: 2013-04-30

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University of California Davis School of Veterinary Medicine

UNITED STATES

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Hans-Joachim Lehmler

Research Interests

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Recent Grants

Articles (20)

Single-cell transcriptomics showed that maternal PCB exposure dysregulated cell type-specific metabolic responses in the livers of female mouse offsprings

Identification of polychlorinated biphenyls (PCBs) and PCB metabolites associated with changes in the gut microbiome of female mice exposed to an environmental PCB mixture

Subacute exposure of male adolescent rats to 2,2′,5,5′-tetrachlorobiphenyl-4-ol via a polymeric implant causes gene expression changes in the brain and metabolomic disruption in serum

Deconjugation of Polychlorinated Biphenyl Sulfates to Hydroxylated PCBs by Anaerobically Cultured Mouse and Human Gut Microbiota

High-Throughput GPCRome Screen of Pollutants Reveals the Activity of Polychlorinated Biphenyls at Melatonin and Sphingosine-1-phosphate Receptors

Elucidating the Metabolism of Chiral PCB95 in Wildtype and Transgenic Mouse Models with Altered Cytochrome P450 Enzymes Using Intestinal Content Screening

Interactions of Polychlorinated Biphenyls and Their Metabolites with the Brain and Liver Transcriptome of Female Mice

Astrocyte Mitochondria Are a Sensitive Target of PCB52 and its Human-Relevant Metabolites

Distribution of 2,2′,5,5′-Tetrachlorobiphenyl (PCB52) Metabolites in Adolescent Rats after Acute Nose-Only Inhalation Exposure

Bisphenol S, bisphenol F, bisphenol a exposure and body composition in US adults

Rebuttal to Correspondence on “Machine Learning-Assisted Identification and Quantification of Hydroxylated Metabolites of Polychlorinated Biphenyls in Animal Samples”

Disposition and metabolomic effects of 2,2′,5,5′-tetrachlorobiphenyl in female rats following intraperitoneal exposure

Structure-Activity Relationship of Lower Chlorinated Biphenyls and Their Human-Relevant Metabolites for Astrocyte Toxicity

Genetic background in the rat affects endocrine and metabolic outcomes of bisphenol F exposure

Photolysis of 3-Nitro-1,2,4-triazol-5-one: Mechanisms and Products

Enantiomeric Fractions Reveal Differences in the Atropselective Disposition of 2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) in Wildtype, Cyp2abfgs-Null, and CYP2A6-Humanized Mice

In vitro release, extraction, and analysis of PCBs and metabolites from polymeric implants

Preparation of Polymeric Implants for the Sustained Release of Polychlorinated Biphenyls (PCBs) and Their Derivatives

Isolation of sex specific PND 1/2 rat cortical primary astrocytes

Prevalence of neonicotinoid insecticides in paired private-well tap water and human urine samples in a region of intense agriculture overlying vulnerable aquifers in eastern Iowa

Collaborators (11)

Anne Kwitek

Stefan Strack

Jonathan Doorn

Aloysius Klingelhutz

Justin Grobe

David Roman

Keri Hornbuckle

Ashutosh Mangalam

William Arnold

Hunter Schroer

Pamela Lein

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