Aloysius Klingelhutz

Professor

Iowa State University

United States

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Professor Aloysius Klingelhutz serves at the University of Iowa in the United States. His research encompasses virology, immunology, and the effects of environmental pollutants on metabolic systems. Recent publications include studies on SARS-CoV-2 infection mechanisms, the impact of polychlorinated biphenyls on gene expression, and the role of adiposity in hormonal responses.

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2020

Collaborators (16)

James Ankrum

Associate Professor

Iowa State University

UNITED STATES

Aloysius Klingelhutz

Research Interests

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Articles (24)

Polychlorinated biphenyls induce immunometabolic switch of antiinflammatory macrophages toward an inflammatory phenotype

Multiple cell types support productive infection and dynamic translocation of infectious Ebola virus to the surface of human skin

Subacute exposure of male adolescent rats to 2,2′,5,5′-tetrachlorobiphenyl-4-ol via a polymeric implant causes gene expression changes in the brain and metabolomic disruption in serum

ACE2-Mediated Infection of Immortalized Human Visceral Adipocytes by SARS-CoV-2

Exposure to PCB52 (2,2′,5,5′-tetrachlorobiphenyl) blunts induction of the gene for uncoupling protein 1 (UCP1) in white adipose

Development and analysis of scaffold-free adipose spheroids

The Impact of High Adiposity on Endometrial Progesterone Response and Metallothionein Regulation

Student-led discussions of landmark discovery articles: a foothold in teaching primary virology literature

Effects of 28-day nose-only inhalation of PCB52 (2,2′,5,5′-Tetrachlorobiphenyl) on the brain transcriptome

Inhalation of 2,2′,5,5′-tetrachlorobiphenyl (PCB52) causes changes to the gut microbiome throughout the gastrointestinal tract

Disposition and metabolomic effects of 2,2′,5,5′-tetrachlorobiphenyl in female rats following intraperitoneal exposure

The Chlamydia trachomatis type III-secreted effector protein CteG induces centrosome amplification through interactions with centrin-2

Updating "Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3',4,4',5-Pentachlorobiphenyl (PCB126)" with additional data on exposure to 2,2',5,5'-tetrachlorobiphenyl (PCB52) or its 4-hydroxy metabolite (4-OH-PCB52).

Native adiponectin plays a role in the adipocyte-mediated conversion of fibroblasts to myofibroblasts

Use of a polymeric implant system to assess the neurotoxicity of subacute exposure to 2,2',5,5'-tetrachlorobiphenyl-4-ol, a human metabolite of PCB 52, in male adolescent rats.

Keratinocyte FABP5-VCP complex mediates recruitment of neutrophils in psoriasis.

Purification, characterization, and cloning of a novel pro-inflammatory secreted protein from <i>Staphylococcus aureus</i>.

Avian influenza A viruses exhibit plasticity in sialylglycoconjugate receptor usage in human lung cells.

Adipocytes are susceptible to Ebola Virus infection

Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3',4,4',5-Pentachlorobiphenyl (PCB126).

Pdgfrα-Cre mediated knockout of the aryl hydrocarbon receptor protects mice from high-fat diet induced obesity and hepatic steatosis

Human Keratinocyte Response to Superantigens.

Human Adipocyte Conditioned Medium Promotes In Vitro Fibroblast Conversion to Myofibroblasts.

PCB126 blocks the thermogenic beiging response of adipocytes

Collaborators (16)

James Ankrum

Robert Davey

Dawn Quelle

Jonathan Doorn

Olena Shtanko

Ryan Sheehy

Karen English

Mary Weber

Jacob Herrmann

Kelly N. Messingham

Robert Faris

Radhika A Patel

Hans-Joachim Lehmler

Francoise Gourronc

Ali Jabbari

Wendy J. Maury

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