Harriet de Wit

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University of Chicago

United States

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Harriet de Wit is a Professor at the University of Chicago in the United States. Her research interests focus on the effects of psychoactive drugs on behavior and brain processes, with a particular emphasis on stimulant use disorder and the neural mechanisms underlying drug responses. Recent publications include studies on the empathogen 3,4-methylenedioxymethamphetamine, the mesocorticolimbic system, and the influence of methamphetamine on learning dynamics and social engagement.

Recent Grants

Grant: Close

Memory effects of stimulant drugs in humans

Open Date: 2012-02-15

Close Date: 2015-01-31

Grant: Close

The genetic basis of impulsive behavior in humans

Open Date: 2011-07-15

Close Date: 2016-04-30

Grant: Close

Is Ecstasy an Empathogen? Effects of MDMA on Social and Emotional Processing

Open Date: 2009-09-30

Close Date: 2013-08-31

Grant: Close

Craving During Smoking Abstinence: Does it Abate or Incubate?

Open Date: 2007-06-01

Close Date: 2009-02-28

Grant: Close

Nicotinic Involvement &Consumption of Alcohol in Humans

Open Date: 2002-09-15

Close Date: 2005-08-31

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Collaborators (5)

Lei Wang

Professor

Ohio State University

UNITED STATES

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Olusola Ajilore

Professor

University of Chicago

UNITED STATES

View details

Niki Sabetfakhri

University of California, San Francisco

UNITED STATES

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matthew nassar

Brown University

UNITED STATES

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Noah Philip

Brown University

UNITED STATES

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Harriet de Wit

Research Interests

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About

Recent Grants

Articles (28)

Methamphetamine-induced adaptation of learning rate dynamics depend on baseline performance

Methamphetamine-induced adaptation of learning rate dynamics depend on baseline performance

The empathogen 3,4-methylenedioxymethamphetamine, but not methamphetamine, increases feelings of global trust

The mesocorticolimbic system in stimulant use disorder

Connectome-based encoding of subjective drug responses to acute oral methamphetamine

Harriet de Wit: What can we learn about behavior and brain processes by studying psychoactive drugs in humans? How can we harmonize behavioral research in humans and nonhuman species?

Effects of methamphetamine on human effort task performance are unrelated to its subjective effects

Effects of methamphetamine on two measures of reward: Euphoria and neural activation to reward cues

Alcohol increases social engagement in dyadic interactions: role of partner’s drug state

In memoriam: Klaus A Miczek, PhD

Low-Dose LSD Alters Early and Late Event-Related Potentials to Emotional Faces

Impact of childhood adversity on acute subjective effects of stimulant and opioid drugs: Evidence from placebo-controlled studies in healthy volunteers

Neural complexity is increased after low doses of LSD, but not moderate to high doses of oral THC or methamphetamine

Psychedelics in Medicine: Can Evidence Keep Up With Enthusiasm?

Greater subjective effects of a low dose of LSD in participants with depressed mood

Title: Frontal-pole Neuromodulation for Impulsivity and Suicidality in Veterans with Mild Traumatic Brain Injury and Common Co-Occurring Mental Health Conditions: Protocol for a Pilot Randomized Controlled Trial (Preprint)

MDMA enhances positive affective responses to social feedback

Social Psychopharmacology: Novel Approaches to Treat Deficits in Social Motivation in Schizophrenia

Does acute stress play a role in the lasting therapeutic effects of psychedelic drugs?

Polygenic contributions to performance on the Balloon Analogue Risk Task

Stimulant-like subjective effects of alcohol are not related to resting-state connectivity in healthy men

Methamphetamine enhances neural activation during anticipation of loss in the monetary incentive delay task

Progress and Puzzles in Psychedelic Therapy

Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity

Drug-induced social connection: both MDMA and methamphetamine increase feelings of connectedness during controlled dyadic conversations

Adolescents are more sensitive than adults to acute behavioral and cognitive effects of THC

Challenges in translational research: MDMA in the laboratory versus therapeutic settings

Repeated low doses of LSD in healthy adults: A placebo‐controlled, dose–response study

Collaborators (5)

Lei Wang

Olusola Ajilore

Niki Sabetfakhri

matthew nassar

Noah Philip

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