Hazem Ghoneim

Assistant Professor

The Ohio State University College of Medicine

United States

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Dr. Hazem Ghoneim is an Assistant Professor at The Ohio State University College of Medicine in the United States. His research focuses on immunology, particularly the mechanisms of T-cell exhaustion and dysfunction, and the role of epigenetic modifications in various diseases, including cancer and Alzheimer's disease. Recent publications highlight his work on CD8+ T-cell dynamics, inflammatory pathways, and novel therapeutic approaches to enhance immune response.

Articles (11)

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2025

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2025

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2024

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2024

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2023

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2023

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2023

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2022

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2021

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2021

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2020

Collaborators (7)

Melissa Leonard

Ohio State University

UNITED STATES

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Patrick Collins

Research Assistant Professor

Ohio State University

UNITED STATES

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Richard S. Bruno

Ohio State University

UNITED STATES

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Dalia Haydar

Assistant Professor

UNITED STATES

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Jacob Yount

Associate Professor

Ohio State University

UNITED STATES

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Jerry Lio

Assistant Professor

Ohio State University

UNITED STATES

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Maciej Pietrzak

Research Assistant Professor

Ohio State University

UNITED STATES

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Hazem Ghoneim

Research Interests

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Articles (11)

Chronic ISG15 Exposure Accelerates CD8+ T-cell Dysfunction while Increasing PD-1 Blockade Sensitivity in Oral Squamous Cell Carcinoma

The NAE1-mediated neddylation operates as an essential post-translational modification checkpoint for effector CD8+ T cells

Microglia-targeted inhibition of miR-17 via mannose-coated lipid nanoparticles improves pathology and behavior in a mouse model of Alzheimer’s disease

DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer’s disease

Functional T cells are capable of supernumerary cell division and longevity

Rebalancing TGFβ1/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy

Aiolos represses CD4<sup>+</sup> T cell cytotoxic programming via reciprocal regulation of T<sub>FH</sub> transcription factors and IL-2 sensitivity.

Epigenetic remodeling by vitamin C potentiates plasma cell differentiation

Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiation.

T cell exhaustion—a memory locked behind scars

Developmental plasticity allows outside-in immune responses by resident memory T cells

Collaborators (7)

Melissa Leonard

Patrick Collins

Richard S. Bruno

Dalia Haydar

Jacob Yount

Jerry Lio

Maciej Pietrzak

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