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Helge Gad

University of Sheffield

United Kingdom

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Research Interests

Cell Biology

30%

Biochemistry

40%

Cancer Biology

40%

Dna Damage

30%

Telomere Biology

20%

Tyrosine Kinase

20%

Autophagy

20%

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Articles7

MTH1 inhibitor TH1579 induces oxidative DNA damage and mitotic arrest in acute myeloid leukemia

Article Link

Year:

2021

NEIL3 prevents senescence in hepatocellular carcinoma by repairing oxidative lesions at telomeres during mitosis

Article Link

Year:

2021

Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma

Article Link

Year:

2021

Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects

Article Link

Year:

2021

Targeting OGG1 arrests cancer cell proliferation by inducing replication stress

Article Link

Year:

2020

MTH1 inhibitor TH588 disturbs mitotic progression and induces mitosis-dependent accumulation of genomic 8-oxodG

Article Link

Year:

2020

AXL and CAV-1 play a role for MTH1 inhibitor TH1579 sensitivity in cutaneous malignant melanoma

Article Link

Year:

2020

Collaborators8

Evert Homan

Karolinska Institutet

SWEDEN

Brinton Seashore-Ludlow

Karolinska Institutet

SWEDEN

Therese M Pham

Karolinska Institutet

SWEDEN

Mikael Altun

Karolinska Institutet

SWEDEN

Bishoy Hanna

Karolinska Institutet

SWEDEN

Sean Rudd

Assistant Professor

Karolinska Institutet

SWEDEN

Päivi Östling

Karolinska Institutet

SWEDEN

Julian Albers

Technical University of Munich

GERMANY

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