Hendrik Marks

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Groupleader/ University Lecturer

Radboud University

Netherlands

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About

Hendrik Marks is a University Lecturer and Groupleader at Radboud University (RU) in the Netherlands. His research focuses on stem cell biology, epigenetics, and organoid technology, as reflected in his recent publications on topics such as methylome profiling, differentiation potential in stem cells, and gene regulatory mechanisms in hepatocytes. He is committed to advancing our understanding of pluripotency and genome integrity in embryonic stem cells.

Recent Grants

Grant: Close

Identification of proteins that inactivate the female X chromosome

Open Date: 2021-04-01

Close Date: 2022-03-31

Grant: Close

Van Gogh grant: Epigenetic mechanisms driving embryonic development

Open Date: 2017-01-01

Close Date:

Grant: Close

864.12.007

Open Date: 2015-06-25

Close Date: 2015-09-03

Grant: Close

NWO VIDI: Mechanisms behind maintenance and exit of ground state pluripotency

Open Date: 2013-07-01

Close Date: 2018-06-30

Grant: Close

Mechanisms behind maintenance and exit of ground state pluripotency

Open Date: 2013-07-01

Close Date: 2018-06-30

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Collaborators (8)

Yaser Atlasi

The Queen's University Belfast

UNITED KINGDOM

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Menno ter Huurne

Leiden University Medical Center

NETHERLANDS

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Edward Curry

Imperial College London

UNITED KINGDOM

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Derk ten Berge

associate professor

Erasmus MC

NETHERLANDS

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Guido van Mierlo

Assistant Professor

Radboud University Medical Center

NETHERLANDS

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René Dirks

Wageningen University & Research

NETHERLANDS

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Miha Modic

Tenure-track Professor of Genomics and Development

Karlsruhe Institute of Technology

GERMANY

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Jo Huiqing Zhou

Radboud University

NETHERLANDS

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Hendrik Marks

Research Interests

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About

Recent Grants

Articles (20)

Methylome profiling of SetDB1 deficient ESCs reveals diverse epigenetic cross-talk during pluripotency

Stem cell culture conditions affect in vitro differentiation potential and mouse gastruloid formation

Stem cell culture conditions affect <i>in vitro</i> differentiation potential and mouse gastruloid formation

Multi-omics analysis reveals distinct gene regulatory mechanisms between primary and organoid-derived human hepatocytes

PRC1 and PRC2 proximal interactome in mouse embryonic stem cells

The exit of naive pluripotency contains a lipid metabolism-induced checkpoint for genome integrity

Integrative omics analysis reveals gene regulatory mechanisms distinguishing organoid-derived hepatocytes from primary human hepatocytes

There is another: H3K27me3-mediated genomic imprinting

H3K27me3 at pericentromeric heterochromatin is a defining feature of the early mouse blastocyst

Human branching cholangiocyte organoids functional bile duct formation

Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction

Developments in pluripotency: a new formative state

A plug and play microfluidic platform for standardized sensitive low-input chromatin immunoprecipitation

Overcoming epigenetic roadblocks

STARR-seq identifies active, chromatin-masked, and dormant enhancers in pluripotent mouse embryonic stem cells.

Two Functional Axes of Feedback-Enforced PRC2 Recruitment in Mouse Embryonic Stem Cells.

Terminal keratinocyte differentiation in vitro is associated with a stable DNA methylome.

In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states.

Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency.

Critical Role for P53 in Regulating the Cell Cycle of Ground State Embryonic Stem Cells.

Collaborators (8)

Yaser Atlasi

Menno ter Huurne

Edward Curry

Derk ten Berge

Guido van Mierlo

René Dirks

Miha Modic

Jo Huiqing Zhou

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