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Henning Jessen

Professor of Bioorganic Chemistry

University of Freiburg

Germany

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Research Interests

Biochemistry

100%

Cell Biology

70%

Transporter Biology

40%

Metabolic Biology

40%

Yeast Biology

30%

Nucleic Acid Chemistry

30%

Enzymology

30%

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Articles30

Oxygen sensor system: Real-time absorbance-based monitoring system for tracking oxygen release from tunable anthracene-endoperoxide molecules

Article Link

Year:

2026

Metabolism of inositol derivatives by the gut microbiome

Article Link

Year:

2025

Pressure Sensing and Kinetic Modeling of Oxygen-Releasing Endoperoxides for Chemically Driven Micro-Actuation

Article Link

Year:

2025

Conservation of heat stress acclimation by the IPK2-type kinases that control the synthesis of the inositol pyrophosphate 4/6-InsP7 in land plants

Article Link

Year:

2025

Expanding the Inositol Pyrophosphate Toolbox: Stereoselective Synthesis and Application of PP‐InsP4 Isomers in Plant Signaling

Article Link

Year:

2025

Neue Werkzeuge für die Inositolpyrophosphat‐Forschung: Stereoselektive Synthese und Einsatz von PP‐InsP₄‐Isomeren in der Pflanzenforschung

Article Link

Year:

2025

Basic features of cellular inositol metabolism as revealed by a newly developed LC-MS method

Article Link

Year:

2025

Pools of Independently Cycling Inositol Phosphates Revealed by Pulse Labeling with 18O-Water

Article Link

Year:

2025

Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in Trypanosoma cruzi.

Article Link

Year:

2025

Tandem inactivation of inositol pyrophosphatases Asp1, Siw14, and Aps1 illuminates functional redundancies in inositol pyrophosphate catabolism in fission yeast.

Article Link

Year:

2025

Orchestration of phosphate homeostasis by the ITPK1-type inositol phosphate kinase in the liverwort Marchantia polymorpha

Article Link

Year:

2024

An Update on Polyphosphate In Vivo Activities

Article Link

Year:

2024

Identification and Characterization of a Blood-Brain Barrier Penetrant Inositol Hexakisphosphate Kinase (IP6K) Inhibitor.

Article Link

Year:

2024

Phytate metabolism is mediated by microbial cross-feeding in the gut microbiota

Article Link

Year:

2024

Activities and genetic interactions of fission yeast Aps1, a Nudix-type inositol pyrophosphatase and inorganic polyphosphatase.

Article Link

Year:

2024

Control of a chemical chaperone by a universally conserved ATPase.

Article Link

Year:

2024

Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8.

Article Link

Year:

2024

ITPK1 is an InsP6/ADP phosphotransferase that controls phosphate signaling in Arabidopsis.

Article Link

Year:

2024

Structures of 3-acetylpyridine adenine dinucleotide and ADP-ribose bound to the electron input module of respiratory complex I

Article Link

Year:

2024

Arg1 from Cryptococcus neoformans lacks PI3 kinase activity and conveys virulence roles via its IP3-4 kinase activity.

Article Link

Year:

2024

Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in the enteric nervous system

Article Link

Year:

2023

Non‐canonical nucleosides: Biomimetic triphosphorylation, incorporation into mRNA and effects on translation and structure

Article Link

Year:

2023

Sangivamycin is preferentially incorporated into viral RNA by the SARS-CoV-2 polymerase

Article Link

Year:

2023

Bacterial Pathogen Infection Triggers Magic Spot Nucleotide Signaling in Arabidopsis thaliana Chloroplasts through Specific RelA/SpoT Homologues

Article Link

Year:

2023

Assigning the Absolute Configuration of Inositol Poly- and Pyrophosphates by NMR Using a Single Chiral Solvating Agent

Article Link

Year:

2023

Cryo‐EM structure of the polyphosphate polymerase VTC reveals coupling of polymer synthesis to membrane transit

Article Link

Year:

2023

Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction

Article Link

Year:

2023

Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast

Article Link

Year:

2023

Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues

Article Link

Year:

2023

The phytase RipBL1 enables the assignment of a specific inositol phosphate isomer as a structural component of human kidney stones

Article Link

Year:

2023

Collaborators16

Yun Chen

Chalmers University of Technology

SWEDEN

Jennifer Andexer

University of Freiburg

GERMANY

Willem M. de Vos

NETHERLANDS

Thorsten Friedrich

Albert-Ludwigs-Universität Freiburg

GERMANY

Beate Schwer

Professor

Weill Cornell Medical College

UNITED STATES

Stefanie M. Kaiser

Ludwig-Maximilians-Universität München

GERMANY

Mariano Bizzarri

Professor

Sapienza University

ITALY

Roberto Docampo

Professor and Eminent Scholar

University of Georgia

UNITED STATES

Gabriel Schaaf

Professor, Chair

GERMANY

Christoph Loenarz

Professor of Pharmaceutical Bioanalytics

University of Freiburg

GERMANY

Patricia Benčić

EPFL (École Polytechnique Fédérale de Lausanne)

SWITZERLAND

Antonella Riccio

University College London

UNITED KINGDOM

Masatoshi Ito

Assistant Professor

St. Marianna University School of Medicine

JAPAN

Masayuki Tanaka

Tokai University

JAPAN

Nam Bui

Amsterdam University Medical Centers

NETHERLANDS

Maja Köhn

Full Professor

University of Freiburg

GERMANY

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Henning Jessen

Professor of Bioorganic Chemistry

How do I reach out?

Contact this professor

Research Interests

Ask ApplyKite AI

Articles30

Oxygen sensor system: Real-time absorbance-based monitoring system for tracking oxygen release from tunable anthracene-endoperoxide molecules

Metabolism of inositol derivatives by the gut microbiome

Pressure Sensing and Kinetic Modeling of Oxygen-Releasing Endoperoxides for Chemically Driven Micro-Actuation

Conservation of heat stress acclimation by the IPK2-type kinases that control the synthesis of the inositol pyrophosphate 4/6-InsP7 in land plants

Expanding the Inositol Pyrophosphate Toolbox: Stereoselective Synthesis and Application of PP‐InsP4 Isomers in Plant Signaling

Neue Werkzeuge für die Inositolpyrophosphat‐Forschung: Stereoselektive Synthese und Einsatz von PP‐InsP₄‐Isomeren in der Pflanzenforschung

Basic features of cellular inositol metabolism as revealed by a newly developed LC-MS method

Pools of Independently Cycling Inositol Phosphates Revealed by Pulse Labeling with 18O-Water

Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in &lt;i&gt;Trypanosoma cruzi&lt;/i&gt;.

Tandem inactivation of inositol pyrophosphatases Asp1, Siw14, and Aps1 illuminates functional redundancies in inositol pyrophosphate catabolism in fission yeast.

Orchestration of phosphate homeostasis by the ITPK1-type inositol phosphate kinase in the liverwort Marchantia polymorpha

An Update on Polyphosphate In Vivo Activities

Identification and Characterization of a Blood-Brain Barrier Penetrant Inositol Hexakisphosphate Kinase (IP6K) Inhibitor.

Phytate metabolism is mediated by microbial cross-feeding in the gut microbiota

Activities and genetic interactions of fission yeast Aps1, a Nudix-type inositol pyrophosphatase and inorganic polyphosphatase.

Control of a chemical chaperone by a universally conserved ATPase.

Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8.

ITPK1 is an InsP<sub>6</sub>/ADP phosphotransferase that controls phosphate signaling in Arabidopsis.

Structures of 3-acetylpyridine adenine dinucleotide and ADP-ribose bound to the electron input module of respiratory complex I

Arg1 from <i>Cryptococcus neoformans</i> lacks PI3 kinase activity and conveys virulence roles via its IP<sub>3-4</sub> kinase activity.

Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in the enteric nervous system

Non‐canonical nucleosides: Biomimetic triphosphorylation, incorporation into mRNA and effects on translation and structure

Sangivamycin is preferentially incorporated into viral RNA by the SARS-CoV-2 polymerase

Bacterial Pathogen Infection Triggers Magic Spot Nucleotide Signaling in Arabidopsis thaliana Chloroplasts through Specific RelA/SpoT Homologues

Assigning the Absolute Configuration of Inositol Poly- and Pyrophosphates by NMR Using a Single Chiral Solvating Agent

Cryo‐EM structure of the polyphosphate polymerase VTC reveals coupling of polymer synthesis to membrane transit

Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction

Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast

Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues

The phytase RipBL1 enables the assignment of a specific inositol phosphate isomer as a structural component of human kidney stones

Collaborators16

Yun Chen

Jennifer Andexer

Willem M. de Vos

Thorsten Friedrich

Beate Schwer

Stefanie M. Kaiser

Mariano Bizzarri

Roberto Docampo

Gabriel Schaaf

Christoph Loenarz

Patricia Benčić

Antonella Riccio

Masatoshi Ito

Masayuki Tanaka

Nam Bui

Maja Köhn

How do I reach out?

Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in <i>Trypanosoma cruzi</i>.