Hiroshi Yamazaki

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Showa Pharmaceutical University

Japan

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Recent Grants

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Prediction system of risk assessments by change the drug metabolism activity in placenta for pregnancy

Open Date: 2020-04-01

Close Date: 2023-03-31

Grant: Close

ヒト薬物相互作用の定量的予測を指向した単一酵素不括化ヒト肝移植マウスモデルの開発

Open Date: 2020-04-01

Close Date: 2023-03-31

Grant: Close

Systematic identification and characterization of essential drug-metabolizing enzyme toward establishment of platform for drug metabolism research in veterinary species

Open Date: 2020-04-01

Close Date: 2023-03-31

Grant: Close

Evaluation for pharmacokinetics of chemicals mediated by flavin-containing monooxygenases using humanized animal models

Open Date: 2019-04-01

Close Date: 2022-03-31

Grant: Close

サリドマイドとアミノ基置換体のヒト化動物とヒト胎盤細胞による体内代謝的活性化評価

Open Date: 2017-04-01

Close Date: 2020-03-31

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Collaborators (4)

Yoichi Tanaka

National Institute of Health Sciences

JAPAN

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Adachi Koichiro

Assistant Professor

Showa Pharmaceutical University

JAPAN

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Yasuhiro Uno

Kagoshima University

JAPAN

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Makiko Shimizu

Showa Pharmaceutical University

JAPAN

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Hiroshi Yamazaki

Research Interests

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Recent Grants

Articles (20)

Novel dog hepatic cytochrome P450 3A293 oxidizes endogenous testosterone and estradiol

Investigation of genetic polymorphisms in pig cytochromes P450 1A2, 2A19, 2C33, 2D25, and 3A22 to elucidate inter-individual variability of hepatic drug oxidations

Tyrosine kinase inhibitors, nilotinib and radotinib, suppress both catalytic function and mRNA expression of human cytochrome P450 2J2 and 2C8

Japanese medicinal drug labeling for use in the clinical setting as informed by pharmacogenomic data on cytochrome P450 enzymes obtained from in silico studies

Triethylamine N-oxygenation mediated by liver and kidney microsomes and recombinant flavin-containing monooxygenase 3 (FMO3) and FMO1 proteins from humans, monkeys, pigs, and dogs

Prediction of Internal Exposures after Virtual Oral Doses of Disparate Chemicals in Rats and Humans Using Simplified Physiologically Based Pharmacokinetic Models with In Silico-Generated Input Parameters

Investigation of pilocarpine oxidative and hydrolytic metabolism in chimeric mice with humanized liver

Contribution of Japanese scientists to drug metabolism and disposition

Substrate inhibition potential of arachidonic acid on 14,15-epoxidation, a biological drug developmental target, mediated by recombinant human cytochrome P450 2J2 and 2C8 enzymes

Kinetics of the inhibition of CYP3A4 and CYP2C19 activity by jabara juice and identification of the responsible inhibitory components

A decreasing plasma concentration of a toxicologically active metabolite 9-carboxymethoxymethylguanine after dialysis – A potential new clinical biomarker for improving encephalopathy in patients treated with acyclovir

Simple confirmation methods for rare but impaired variants of human flavin-containing monooxygenase 3 (FMO3) found in an updated genome resource databank

Variants of Flavin-Containing Monooxygenase 3 Found in Subjects in an Updated Database of Genome Resources

A family study of compound variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found by urinary phenotyping for trimethylaminuria

Roles of human cytochrome P450 3A4/5 in dexamethasone 6β-hydroxylation mediated by liver microsomes and humanized liver in chimeric mice metabolically suppressed with azamulin

High hepatic and plasma exposures of atorvastatin in subjects harboring impaired cytochrome P450 3A4∗16 modeled after virtual administrations and possibly associated with statin intolerance found in the Japanese adverse drug event report database

The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro

HepaSH cells: Experimental human hepatocytes with lesser inter-individual variation and more sustainable availability than primary human hepatocytes

Newly Identified Tree ShrewCytochrome P4502A13 is Expressed in Liver and Lung and Encodes a Functional Drug-Metabolizing Enzyme Similar to DogCytochrome P4502A13 and PigCytochrome P4502A19

Novel Cytochrome P450 2C94 Functionally Metabolizes Diclofenac and Omeprazole in Dogs

Collaborators (4)

Yoichi Tanaka

Adachi Koichiro

Yasuhiro Uno

Makiko Shimizu

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