Hirotaka Murase

Assistant Professor

Sojo University

Japan

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Dr. Hirotaka Murase is an Assistant Professor at Sojo University, Japan. His research primarily focuses on nucleic acid interactions, RNA modifications, and the development of novel therapeutic agents for viral infections and cancer. Recent publications include investigations into nucleoside derivatives for RNA catalysis, small molecule-RNA interactions, and innovations in PCR primer design for DNA synthesis.

Hirotaka Murase

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Articles (18)

Crystallographic analysis of G-clamp–RNA complex assisted by large scale RNA-binding profile

New Nucleoside Derivatives for Hybridization-Assisted Catalysis of Site-Selective Acetylation of 2′-OH of RNA

Large-scale analysis of small molecule-RNA interactions using multiplexed RNA structure libraries

Development of hydrophobic tag purifying monophosphorylated RNA for chemical synthesis of capped mRNA and enzymatic synthesis of circular mRNA

2′-β-Methylselenyl nucleos(t)ide analogs as reverse transcriptase inhibitors against diverse HIV mutants

Development of PCR primers enabling the design of flexible sticky ends for efficient concatenation of long DNA fragments

Site-specific acetyl modification of 2′-OH of RNA by an oligonucleotide acetylating reagent

Ibuprofen‑derived nitric oxide donors with a high affinity to human serum albumin induce cell death in pancreatic cancer cells through a non‑caspase 3/7‑mediated pathway

Manipulating nucleic acids-regulation of gene expression through higher order structure and chemical modification

Novel Diclofenac-NO Donor With High Affinity for Human Serum Albumin Induces Endoplasmic Reticulum Stress-mediated Cell Death in Human Pancreatic Cancer Cells

The Effect of γ Phosphate Modified Deoxynucleotide Substrates on PCR Activity and Fidelity

Cap analogs with a hydrophobic photocleavable tag enable facile purification of fully capped mRNA with various cap structures

Site-Specific Tritium Labeling at the Predefined Internal Position of the Chemically-Modified RNA

Development of a selective ligand for G–G mismatches of CGG repeat RNA inducing the RNA structural conversion from the G-quadruplex into a hairpin-like structure

Application of the Functionality Transfer Oligodeoxynucleotide for the Site-Selective Modification of RNA with a Divers Molecule

Development of a selective ligand for G-G mismatches of CGG repeat RNA inducing the RNA structural conversion from the G-quadruplex into a hairpin-like structure

Artificial Host Molecules to Covalently Capture 8-Nitro-cGMP in Neutral Aqueous Solutions and in Cells

Protection of all cleavable sites of DNA with the multiple CGCG or continuous CGG sites from the restriction enzyme, indicative of simultaneous binding of small ligands

Collaborators (9)

Akash Chandela

Naoko Abe

Haruka Hiraoka

Kazumitsu Onizuka

Tairin Kawasaki

Kaoru Komatsu

Yasuaki Kimura

Shigeki Sasaki

Satoru Karasawa

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