Yasuaki Kimura

Associate Professor

Nagoya University

Japan

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About

Yasuaki Kimura is an Associate Professor at Nagoya University in Japan. His research focuses on biochemical techniques for nucleic acid modifications, chemical ligation, and the development of innovative methods for mRNA delivery and purification. Recent articles highlight his work on intramolecular cross-activation of DNA, mRNA structure-activity relationship studies, and novel applications for enhancing nucleic acid stability.

Articles (20)

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2025

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2020

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2020

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2020

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2020

Collaborators (15)

Kosuke Nakamoto

Brandeis University

UNITED STATES

Yasuaki Kimura

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Articles (20)

Chemical autoligation with phosphorothioate- and sulfonamide-terminated DNA via intramolecular cross-activation

Concise Affinity‐Based Purification of Ligated mRNA for Structure‐Activity Relationship Studies of Nucleosugar Modification Patterns

Characterization of nuclease stability and poly(A)-binding protein binding activity of chemically modified poly(A) tail for in vivo applications

Facile DNA chemical ligation under mild conditions enabled by 1-cyano-4-(dimethylamino)pyridinium tetrafluoroborate (CDAP)

In vivo demonstration of enhanced mRNA delivery by cyclic disulfide-containing lipid nanoparticles for facilitating endosomal escape

Intracellular Delivery of Antisense Oligonucleotides by Tri‐Branched Cyclic Disulfide Units

Development of hydrophobic tag purifying monophosphorylated RNA for chemical synthesis of capped mRNA and enzymatic synthesis of circular mRNA

2′-β-Methylselenyl nucleos(t)ide analogs as reverse transcriptase inhibitors against diverse HIV mutants

Development and Comparison of 4-Thiouridine to Cytidine Base Conversion Reaction

Development of PCR primers enabling the design of flexible sticky ends for efficient concatenation of long DNA fragments

Synthesis of nucleoside oligophosphates by electrophilic activation of phosphorothioate

Development of Fluorophosphoramidate as a Biocompatibly Transformable Functional Group and its Application as a Phosphate Prodrug for Nucleoside Analogs

Complete Chemical Synthesis of Minimal Messenger RNA by Efficient Chemical Capping Reaction

Completely Chemically Synthesized Long DNA Can be Transcribed in Human Cells

Antisense Oligonucleotide Modified with Disulfide Units Induces Efficient Exon Skipping in mdx Myotubes through Enhanced Membrane Permeability and Nucleus Internalization

Structure, Synthesis and Inhibition Mechanism of Nucleoside Analogues as HIV‐1 Reverse Transcriptase Inhibitors (NRTIs)

Free-Energy Calculation of Ribonucleic Inosines and Its Application to Nearest-Neighbor Parameters.

Phosphorothioate Modification of mRNA Accelerates the Rate of Translation Initiation to Provide More Efficient Protein Synthesis

Phosphorothioate Modification of mRNA Accelerates the Rate of Translation Initiation to Provide More Efficient Protein Synthesis

Quantification of native mRNA dynamics in living neurons using fluorescence correlation spectroscopy and reduction-triggered fluorescent probes

Collaborators (15)

Kosuke Nakamoto

Satoshi Uchida

Masahito Inagaki

hiroshi abe

Akiyoshi Hirayama

Tetsuro Suzuki

Hirotaka Murase

Naoko Abe

Fumiaki Tomoike

Daisuke Kawaguchi

Haruka Hiraoka

Junichi Iwakiri

Tairin Kawasaki

Akira Horii

Fumitaka Hashiya

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