Holger Gerhardt

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Group Leader/Professor

Germany

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About

Holger Gerhardt is a Professor and Group Leader at the Max-Delbrueck-Center for Molecular Medicine in Germany. His research focuses on cardiovascular diseases, particularly heart failure, vascular development, and cellular mechanisms involved in tissue repair and regeneration. Recent publications highlight his work on multi-omics integration, single-cell RNA sequencing, and the role of mechanosensitive channels in coronary artery development.

Recent Grants

Grant: Close

ATTRACT: Arterial flow as attractor for endothelial cell migration

Open Date: 2018-01-01

Close Date: 2023-12-01

Grant: Close

Dynamic focussing photoacoustic microscopy of angiogenesis in vivo

Open Date: 2017-01-01

Close Date:

Grant: Close

De rol van cyclisch AMP-afhankelijk proteïne kinase A (PKA) in de regulatie van de endotheliale barrière tijdens ontwikkeling en homeostase van het vasculair systeem.

Open Date: 2015-01-01

Close Date: 2018-12-31

Grant: Close

Mechano-dependency of early bone healing, angiogenesis, and their interplay across ages

Open Date: 2014-01-01

Close Date:

Grant: Close

Mechanisms of vascular patterning in development and disease - FROM CELLS TO NETWORKS

Open Date: 2013-06-01

Close Date: 2014-09-30

Articles (26)

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2021

Collaborators (18)

Sofia K. Forslund

GERMANY

Holger Gerhardt

Research Interests

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About

Recent Grants

Articles (26)

Deep phenotyping of heart failure with preserved ejection fraction through multi‐omics integration

Connexin 41.8 governs timely haematopoietic stem and progenitor cell specification.

How vascularization is reciprocally coupled to chondrogenesis and osteogenesis in bone healing: lessons from the growth plate.

Mechanosensitive PIEZO2 channels shape coronary artery development.

Single-Cell RNA Sequencing Delineates Renal Anti-Fibrotic Mechanisms Mediated by TRPC6 Inhibition.

Metabolic and Immune Crosstalk in Cardiovascular Disease.

Endothelial deletion of adipose triglyceride lipase protects against heart failure with preserved ejection fraction.

Polarity-JaM: an image analysis toolbox for cell polarity, junction and morphology quantification.

Protein kinase A regulates ferroptosis by controlling GPX4 m<sup>6</sup>A modification through phosphorylation of ALKBH5.

External Mechanical Stability Regulates Hematoma Vascularization in Bone Healing Rather than Endothelial YAP/TAZ Mechanotransduction.

In preprints: keeping endothelial cell specification and vascular development in check.

A 96-wells fluidic system for high-throughput screenings under laminar high wall shear stress conditions

Protocol of the Berlin Long-term Observation of Vascular Events (BeLOVE): a prospective cohort study with deep phenotyping and long-term follow up of cardiovascular high-risk patients

External mechanical loading overrules cell-cell mechanical communication in sprouting angiogenesis during early bone regeneration.

Single-cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma.

Svep1 stabilises developmental vascular anastomosis in reduced flow conditions

WASp controls oriented migration of endothelial cells to achieve functional vascular patterning

Vascular and Liver Homeostasis in Juvenile Mice Require Endothelial Cyclic AMP-Dependent Protein Kinase A.

Brief Research Report: Quantitative Analysis of Potential Coronary Microvascular Disease in Suspected Long-COVID Syndrome.

Formation and Maintenance of the Natural Bypass Vessels of the Brain.

WASp controls oriented migration of endothelial cells to achieve functional vascular patterning

A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth

Blood flow meets mitophagy

WASp controls oriented migration of endothelial cells to achieve functional vascular patterning

Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis

The Genetic Basis of Moyamoya Disease.

Collaborators (18)

Sofia K. Forslund

keith mostov

Ute Krügel

Leif-Hendrik Boldt

Michael Welsh

Norbert Hübner

Andre Rosa

Susana Cardoso de Freitas

Marco Castro

Wei Gu

Dominik N Muller

Ana Rita Grosso

Christoph Harms

Baptiste Coxam

Collin Goetze

Joachim Weber

Jorge Andrade

Burkert Pieske

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