isabelle lucet

Division Head

Walter and Eliza Hall Institute of Medical Research

Australia

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Dr. Isabelle Lucet is the Division Head at the Walter and Eliza Hall Institute of Medical Research in Australia. Her research focuses on structural studies of pseudokinases, including the PEAK family and their implications in cancer signaling pathways. Recent publications highlight her work on the molecular mechanisms of DCLK1 mutations, effector recognition in immune receptors, and innovative approaches to targeting kinases for therapeutic purposes.

Articles (9)

Year:

2024

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2024

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2023

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2022

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2021

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2021

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2021

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2020

Year:

2020

Collaborators (6)

Onisha Patel

Walter and Eliza Hall Institute of Medical Research

AUSTRALIA

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Maël BAUDIN

Professeur junior

Université d'Angers

FRANCE

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Michael Roy

University of Dundee

UNITED KINGDOM

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Matthias Ernst

AUSTRALIA

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David Goldstone

Associate Professor

University of Auckland

NEW ZEALAND

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James Murphy

Laboratory Head

Walter and Eliza Hall Institute of Medical Research

AUSTRALIA

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isabelle lucet

Research Interests

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Articles (9)

Molecular dissection of the pseudokinase ZED1 expands effector recognition to the tomato immune receptor ZAR1

View from the PEAKs: Insights from structural studies on the PEAK family of pseudokinases

Structure-Guided Prediction of the Functional Impact of DCLK1 Mutations on Tumorigenesis

Distinct PEAK3 interactors and outputs expand the signaling potential of the PEAK pseudokinase family

Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1

The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs

Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory αC helix

The PEAK family of pseudokinases, their role in cell signalling and cancer

Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the Pathway

Collaborators (6)

Onisha Patel

Maël BAUDIN

Michael Roy

Matthias Ernst

David Goldstone

James Murphy

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