James Baker

University College London

United Kingdom

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Articles (12)

Year:

2024

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2024

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2022

Year:

2021

Collaborators (10)

James Irving

Principal Research Fellow (Assoc. Prof.)

University College London

UNITED KINGDOM

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Jesper Wengel

Professor

University of Southern Denmark

DENMARK

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Johan Palmfeldt

Associate Professor

Aarhus University

DENMARK

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Michael Porter

University College London

UNITED KINGDOM

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Helen Fielding

University College London

UNITED KINGDOM

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Kenneth Howard

Associate Professor

Aarhus University

DENMARK

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christopher scott

The Queen's University Belfast

UNITED KINGDOM

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Charlotte Rivas

King’s College London

UNITED KINGDOM

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Vijay Chudasama

University College London

UNITED KINGDOM

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Nicholas J. Long

Imperial College London

UNITED KINGDOM

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James Baker

Research Interests

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Articles (12)

The Nitrile Bis-Thiol Bioconjugation Reaction

Chemo- and regio-selective differential modification of native cysteines on an antibody via the use of dehydroalanine forming reagents

Trifunctional Dibromomaleimide Reagents Built Around A Lysine Scaffold Deliver Site‐selective Dual‐modality Antibody Conjugation

A Light‐Induced Decarboxylative‐Elimination of Substituted Maleimides as a Strategy Towards Triggered Photorelease

Modular Chemical Construction of IgG-like Mono- and Bispecific Synthetic Antibodies (SynAbs)

Enabling the formation of native mAb, Fab′ and Fc-conjugates using a bis-disulfide bridging reagent to achieve tunable payload-to-antibody ratios (PARs)

Intramolecular thiomaleimide [2 + 2] photocycloadditions: stereoselective control for disulfide stapling and observation of excited state intermediates by transient absorption spectroscopy

Albumin Biomolecular Drug Designs Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Functionalized Assembly

A novel thiol-labile cysteine protecting group for peptide synthesis based on a pyridazinedione (PD) scaffold

Dual reactivity disulfide bridging reagents; enabling new approaches to antibody fragment bioconjugation

Unearthing the unique stability of thiophosphonium-C-terminal cysteine adducts on peptides and proteins

New Bifunctional Chelators Incorporating Dibromomaleimide Groups for Radiolabeling of Antibodies with Positron Emission Tomography Imaging Radioisotopes

Collaborators (10)

James Irving

Jesper Wengel

Johan Palmfeldt

Michael Porter

Helen Fielding

Kenneth Howard

christopher scott

Charlotte Rivas

Vijay Chudasama

Nicholas J. Long

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