Vijay Chudasama

University College London

United Kingdom

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Articles (17)

Year:

2024

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2024

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2024

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2024

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2024

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2023

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2023

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2023

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2023

Substituted pyridazinediones (PDs) enable reversible and tuneable cysteine modification with exemplification on peptides, proteins and hydrogels.

Year:

2023

Year:

2023

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2023

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2023

Year:

2022

Year:

2022

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2022

Year:

2022

Collaborators (10)

James Irving

Principal Research Fellow (Assoc. Prof.)

University College London

UNITED KINGDOM

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Jesper Wengel

Professor

University of Southern Denmark

DENMARK

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Shannon Tracey

The Queen's University Belfast

UNITED KINGDOM

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James Baker

University College London

UNITED KINGDOM

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Johan Palmfeldt

Associate Professor

Aarhus University

DENMARK

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Michael Porter

University College London

UNITED KINGDOM

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Kenneth Howard

Associate Professor

Aarhus University

DENMARK

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christopher scott

The Queen's University Belfast

UNITED KINGDOM

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Carolyn R. Bertozzi

Stanford University

UNITED STATES

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Jaime A. S. Coelho

PORTUGAL

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Vijay Chudasama

Research Interests

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Articles (17)

The Nitrile Bis-Thiol Bioconjugation Reaction

Modular Semisynthetic Approach to Generate T Cell-Dependent Bispecific Constructs from Recombinant IgG1 Antibodies

Macrocyclic Dual‐Locked “Turn‐On” Drug for Selective and Traceless Release in Cancer Cells

Macrocyclic Dual‐Locked “Turn‐On” Drug for Selective and Traceless Release in Cancer Cells

Chemo- and regio-selective differential modification of native cysteines on an antibody via the use of dehydroalanine forming reagents

Trifunctional Dibromomaleimide Reagents Built Around A Lysine Scaffold Deliver Site‐selective Dual‐modality Antibody Conjugation

A Light‐Induced Decarboxylative‐Elimination of Substituted Maleimides as a Strategy Towards Triggered Photorelease

Modular Chemical Construction of IgG-like Mono- and Bispecific Synthetic Antibodies (SynAbs)

Enabling the formation of native mAb, Fab′ and Fc-conjugates using a bis-disulfide bridging reagent to achieve tunable payload-to-antibody ratios (PARs)

Use of pyridazinediones for tuneable and reversible covalent cysteine modification applied to peptides, proteins and hydrogels

Recent advances in N- and C-terminus cysteine protein bioconjugation

Chemical generation of checkpoint inhibitory T cell engagers for the treatment of cancer

Rapid access to potent bispecific T cell engagers using biogenic tyrosine click chemistry

Albumin Biomolecular Drug Designs Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Functionalized Assembly

A novel thiol-labile cysteine protecting group for peptide synthesis based on a pyridazinedione (PD) scaffold

Dual reactivity disulfide bridging reagents; enabling new approaches to antibody fragment bioconjugation

Enabling the next steps in cancer immunotherapy: from antibody-based bispecifics to multispecifics, with an evolving role for bioconjugation chemistry

Collaborators (10)

James Irving

Jesper Wengel

Shannon Tracey

James Baker

Johan Palmfeldt

Michael Porter

Kenneth Howard

christopher scott

Carolyn R. Bertozzi

Jaime A. S. Coelho

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