James Breen

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Chief Data Scientist

Telethon Kids Institute

Australia

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About

James Breen is the Chief Data Scientist at the Telethon Kids Institute in Australia. His research primarily focuses on epigenomics, gene expression dynamics, and disease susceptibility, as evidenced by his recent publications. Notable studies include investigations into chromatin accessibility in regulatory T cells and the role of the progesterone receptor in ovulatory transcription. He also contributes to advancing bioinformatics applications, such as tools for detecting genomic alterations in acute lymphoblastic leukemia.

Recent Grants

Grant: Close

Defining the contribution of epigenetics to the intergenerational cycle of type 2 diabetes in Aboriginal people.

Open Date: 2022-04-01

Close Date: 2024-04-01

Grant: Close

Predicting Renal, Ophthalmic and Heart Events in the Aboriginal Community: The PROPHECY Diabetes Multi-Omics Cohort Study

Open Date: 2021-10-01

Close Date: 2025-09-01

Grant: Close

Using 3D genomics to functionally connect genetic risk of Type 1 diabetes to the genes that drive loss of immune tolerance

Open Date: 2021-10-01

Close Date: 2023-09-01

Grant: Close

Repurposing Marine By-Products or raw Materials for the Development and Production of Functional Foods and Bioactives to Improve Human Health and Coastal Community Sustainability

Open Date: 2021-10-01

Close Date: 2026-09-01

Grant: Close

UNDERSTANDING THE BENEFITS AND LIMITATIONS OF METAPHASE II SPINDLE TRANSFER

Open Date: 2021-01-01

Close Date: 2025-12-01

Articles (10)

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2023

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2023

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2023

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2023

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2023

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2023

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2023

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2022

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2022

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2022

Collaborators (20)

Daniel Poppe

University of Western Australia

AUSTRALIA

James Breen

Research Interests

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About

Recent Grants

Articles (10)

Transient naive reprogramming corrects hiPS cells functionally and epigenetically

DraculR: A Web-Based Application for In Silico Haemolysis Detection in High-Throughput microRNA Sequencing Data

Topologically associating domains in the POLLED region are the same for Angus‐ and Brahman‐specific Hi‐C reads from F1 hybrid fetal tissue

Case Report: Rare <i>IKZF1</i> Gene Fusions Identified in Neonate with Congenital <i>KMT2A</i>-Rearranged Acute Lymphoblastic Leukemia

Circulating epigenomic biomarkers correspond with kidney disease susceptibility in high-risk populations with type 2 diabetes mellitus

Parallel recovery of chromatin accessibility and gene expression dynamics from frozen human regulatory T cells

Progesterone receptor mediates ovulatory transcription through RUNX transcription factor interactions and chromatin remodelling

Placental Transcription Profiling in 6–23 Weeks’ Gestation Reveals Differential Transcript Usage in Early Development

3DFAACTS-SNP: using regulatory T cell-specific epigenomics data to uncover candidate mechanisms of type 1 diabetes (T1D) risk

RaScALL: Rapid (Ra) screening (Sc) of RNA-seq data for prognostically significant genomic alterations in acute lymphoblastic leukaemia (ALL)

Collaborators (20)

Daniel Poppe

Sam Buckberry

Cynthia Bottema

Barbara McClure

Ryan Lister

Natasha Howard

Tina Bianco-Miotto

Andrew Laslett

Charlotte Downes

Anya Arthurs

Melanie D Smith

Deborah L. White

Claire Roberts

Alex de Mendoza

Scott Maxwell

John L. Williams

Qianhui Wan

Katherine A. Pillman

Owen Rackham

Shalem Leemaqz

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