James Hodgkinson

Lecturer

University of Leicester

United Kingdom

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James Hodgkinson is a Lecturer at the University of Leicester, UK. His research focuses on histone deacetylase (HDAC) inhibitors, specifically the development and optimization of PROTACs for targeted degradation of Class I HDACs. Recent articles highlight his work on allosteric regulation of HDAC complexes and the implications of selective degradation in cancer cell apoptosis.

Articles (13)

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2025

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2025

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2025

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2025

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2024

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2024

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2023

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2023

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2022

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2022

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2020

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2020

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2020

Collaborators (3)

Robert McKenna

UNITED STATES

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John W R Schwabe

University of Leicester

UNITED KINGDOM

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Robert Lahue

Professor

National University of Ireland Galway

IRELAND

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James Hodgkinson

Research Interests

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Articles (13)

Off-target binding of the histone deacetylase inhibitor vorinostat to carbonic anhydrase II and IX

The Allosteric Regulator Inositol Phosphate Dramatically Affects the Efficacy and Selectivity of Inhibitors for Different HDAC Complexes

Targeted Degradation of Class 1 HDACs With PROTACs is Highly Effective at Inducing DLBCL Cell Death

Synthetic and structure–activity studies of SP2577 and TCP towards LSD1 targeting PROTACs

MDM2 Antagonist Idasanutlin Reduces HDAC1/2 Abundance and Corepressor Partners but Not HDAC3

Cereblon-recruiting proteolysis targeting chimeras (PROTACs) can determine the selective degradation of HDAC1 over HDAC3

Comprehensive Transcriptomic Analysis of Novel Class I HDAC Proteolysis Targeting Chimeras (PROTACs)

PROTAC chemical probes for histone deacetylase enzymes

Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells

A ‘click’ chemistry approach to novel entinostat (MS-275) based class I histone deacetylase proteolysis targeting chimeras

Bifunctional HDAC Therapeutics: One Drug to Rule Them All?

HDAC3 deacetylates the DNA mismatch repair factor MutSβ to stimulate triplet repeat expansions

PROTAC-mediated degradation of class I histone deacetylase enzymes in corepressor complexes

Collaborators (3)

Robert McKenna

John W R Schwabe

Robert Lahue

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