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James Thaventhiran

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MRC Toxicology Unit

United Kingdom

Research Interests

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Professors in United Kingdom Professors in Immunology Immunology professors in United Kingdom

Recent Grants

Grant: Open

Lymph nodE single cell Genomics AnCestrY immunity, infection, inflammation and immunisation (LEGACY IIII) Network

Open Date: 2025-11-01

Close Date: 2029-11-01

Grant: Open

Increasing vaccine antibody durability

Open Date: 2025-09-01

Close Date: 2030-08-31

Grant: Open

From mechanism to clinical translation: Understanding the off- and on-target toxicities of nucleic-acid-dependent therapeutics

Open Date: 2025-08-31

Close Date: 2030-08-31

Grant: Close

SARS COV2 vaccine ResPonse In Obesity - SCORPIO study

Open Date: 2021-08-11

Close Date: 2023-03-30

Grant: Close

COV-AD: COVID infection in patients with antibody deficiency

Open Date: 2021-02-01

Close Date: 2022-11-30

Articles (20)

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Collaborators (29)

Michelle Ruhle

University of Melbourne

AUSTRALIA

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Susanna Dunachie

Professor at University of Oxford

University of Oxford

UNITED KINGDOM

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Nicholas Matheson

Associate Professor of Virology

University of Cambridge

UNITED KINGDOM

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Indra Roux

University of Cambridge

UNITED KINGDOM

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UNITED KINGDOM

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Timo Kohler

Junior Principle Investigator

University Medical Center Hamburg-Eppendorf

GERMANY

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C. Mark Smales

UNITED KINGDOM

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Martin Potts

UNITED KINGDOM

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University of Oxford

UNITED KINGDOM

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Sian Faustini

University of Birmingham

UNITED KINGDOM

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Nathalie Kingston

Research Professor

University of Cambridge

UNITED KINGDOM

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Kenneth G. C. Smith

Walter and Eliza Hall Institute of Medical Research

AUSTRALIA

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David Bending

University of Birmingham

UNITED KINGDOM

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Gavin Screaton

Head Medical Sciences Division, Dean of Medicine

University of Oxford

UNITED KINGDOM

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University of Oxford

UNITED KINGDOM

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Eleanor Barnes

Professor of Hepatology and Experimental Medicine

University of Oxford

UNITED KINGDOM

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Kiran Raosaheb Patil

Professor of Molecular Systems Biology

University of Cambridge

UNITED KINGDOM

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Charlotte Summers

Professor of Medicine

University of Southampton

UNITED KINGDOM

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James Thaventhiran

Research Interests

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Recent Grants

Articles (20)

PI3Kδ in CD4<SUP>+</SUP> T cells protects against lung metastases through IFNγ-induced tumor senescence

Age-associated defect in ADCC response to COVID-19 vaccine

Dynamic impact of bivalent COVID-19 vaccine boosters on systemic and mucosal antibody and T cell immunity.

Near-cognate tRNAs dominate codon decoding times in simulated ribosomes

Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances

A pan-immunotherapy signature to predict intratumoral CD8+ T cell expansions

Intratumoral antigen signaling traps CD8 + T cells to confine exhaustion to the tumor site

Rapid discovery of monoclonal antibodies by microfluidics-enabled FACS of single pathogen-specific antibody-secreting cells.

Bioengineered small extracellular vesicles deliver multiple SARS‐CoV‐2 antigenic fragments and drive a broad immunological response

Extensive PFAS accumulation by human gut bacteria

Tissue-resident regulatory T cells exert dualistic anti-tumour and pro-repair function in the exocrine pancreas

Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens.

Accelerated waning of the humoral response to COVID-19 vaccines in obesity

Atypical B cells and impaired SARS-CoV-2 neutralization following heterologous vaccination in the elderly.

Translation of in vitro-transcribed RNA therapeutics

Prevalence of CFTR variants in PID patients with bronchiectasis - an important modifying co-factor

Age-associated B cells predict impaired humoral immunity after COVID-19 vaccination in patients receiving immune checkpoint blockade.

N<sup>1</sup>-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting.

Fate-mapping lymphocyte clones and their progenies from induced antigen-signals identifies temporospatial behaviours of T cells mediating tolerance

Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma

Collaborators (29)

Michelle Ruhle

Susanna Dunachie

Nicholas Matheson

Indra Roux

Tsz Kin Mark Cheng

I. Sadaf Farooqi

Anne Willis

James R Edgar

Timo Kohler

C. Mark Smales

Martin Potts

Martijn Schuijs

Patrick Chinnery

Tobias von der Haar

Agatha van der Klaauw

Katarzyna Kania

Lise Estcourt

Sian Faustini

Nathalie Kingston

Kenneth G. C. Smith

David Bending

Gavin Screaton

Lajos Kalmár

Nobuhiro Morone

Tomasz S Kaminski

Anthony Brown

Eleanor Barnes

Kiran Raosaheb Patil

Charlotte Summers

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